Featured Article: KLF-4 expression in oral carcinoma cells


Expression and regulation of Krüppel-like factor 4 (KLF4) is studied in genomic DNA isolated from nine different oral carcinoma cell lines and a normal keratinocyte line. The data demonstrated that hypermethylation at a narrow range of the promoter region down-regulates KLF4 expression, and suggests that the loss of expression by the hypermethylation contributes to oral carcinoma progression.

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Aims and scope

BMC Oral Health is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of disorders of the mouth, teeth and gums, as well as related molecular genetics, pathophysiology, and epidemiology.


  • Christopher Morrey, BioMed Central

Section Editors

  • Alpdogan Kantarci, Forsyth Institute
  • Rodrigo Marino, University of Melbourne
  • Fausto Mendes, University of São Paulo
  • Peter Robinson, University of Sheffield
  • Anton Sculean, Universität Bern
  • Hidenobu Senpuku, National Institute of Infectious Diseases