Prevalence of apical periodontitis and endodontic treatment in a Kosovar adult population
© Kamberi et al; licensee BioMed Central Ltd. 2011
Received: 15 March 2011
Accepted: 29 November 2011
Published: 29 November 2011
Despite numerous studies on the prevalence of apical periodontitis (AP) and endodontic treatment in diverse geographical populations, there are currently no data on the prevalence of these conditions in populations of adults native to Kosovo. Therefore, little is known about how widespread these conditions are, and whether there is any correlation between root canal treatment and AP. The purpose of our research was to address this anomaly by investigating AP and endodontic treatment in an adult Kosovar population based on radiographic examination.
The sample used for this study consisted of randomly selected individuals referred to the University Dentistry Clinical Center of Kosovo in the years 2006-2007. Orthopantomographs of 193 patients were evaluated. The periapical status of all teeth (with the exception of third molars) was examined according to Ørstavik's Periapical Index. The quality of the root canal filling was rated as 'adequate' or 'inadequate' based on whether all canals were filled, the depth of fill relative to the radiographic apex and the quality of compaction (absence/presence of voids). Data were analyzed statistically using the Chi-square test and calculation of odds ratios.
Out of 4131 examined teeth, the prevalence of apical periodontitis (AP) and endodontic treatment was 12.3% and 2.3%, respectively. Of 95 endodontically-treated teeth, 46.3% were associated with AP. The prevalence of AP increased with age. The prevalence in subjects aged over 60 years old (20.2%) was higher than in other age groups. A statistically significant difference was found for the frequency of endodontically-treated teeth associated with AP in the 40-49 year age group (P < 0.001). Of some concern was the discovery that only 30.5% of the endodontically-treated teeth examined met the criteria of an acceptable root canal filling. Inadequately root-filled teeth were associated with an increased AP risk.
The prevalence of AP and the frequency of endodontically-treated teeth with AP in this Kosovar population are higher than those found in other countries. Inadequate root canal fillings were associated with an increased prevalence of AP.
Apical periodontitis (AP) is a multifactorial condition resulting from the interaction of many factors, predominantly bacteria . It is characterized by a reaction of the periapical tissues to irritants diffusing at relatively low intensity and over an extended duration from an inflamed or necrotic pulp or a failed endodontic treatment . Bacteria and their toxins can reach the pulp space via dental caries, trauma, or operative procedures [3, 4] and can then advance into the periapical tissues, where they meet the various factors of the host defense systems .
The biological and therapeutic aim of endodontic treatment is either to prevent AP or to create optimal conditions for healing, based on the removal of infection and elimination of bacteria from the root canal system and prevention of re-infection. Endodontic treatment is widely recognized as a highly intricate task and epidemiological studies report that the frequency of teeth containing poor quality endodontic treatments is high [4–6]. Failure of a root filling is associated with inadequate endodontic treatment, through either technical error or insurmountable difficulty in the canal system of the tooth in question [7, 8]. In several epidemiological studies, poor quality endodontic treatment was found to be associated with AP [9–11], which is commonly observed in root-filled teeth. The healing rate of patients experiencing AP after endodontic treatment in a general practice has been estimated to be as low as 50-75% [6, 9, 12, 13].
Many authors have used clinical and radiologic criteria in assessing the quality of endodontic treatment and its correlation with apical lesions [14–16]. Apical radiography provides important information on the potential progression, regression and/or persistence of AP [17, 18].
The literature contains a number of studies that present data regarding the prevalence of AP and endodontically-treated teeth, and these vary with regard to study populations, radiographic methods and classifications of AP used [9–11, 19–26].
However, despite information from other ethnic groups, studies on periapical health have not yet been performed in Kosovo. No data are available on the prevalence of AP in either unfilled or root-filled teeth in the Kosovar population. The purpose of this study was therefore to use radiographic examination to investigate the prevalence of AP and endodontic treatment in an adult Kosovar population and to reveal any correlation between these conditions.
The protocols used in this study have been approved by the Ethical Board of the University Dentistry Clinical Center of Kosovo, in Prishtina, Kosovo.
The sample used for this study consisted of randomly selected individuals referred by general dentists to the University Dentistry Clinical Center of Kosovo in the years 2006-2007. Orthopantomographs (OPGs) were selected by an independent observer. Radiographs of patients less than 18 years of age and/or with less than 10 standing teeth (including third molars) were excluded. Also excluded were any OPGs that were damaged in any way or were of poor quality (i.e. poor coverage of the periapical region, marked changes in radiographic density and images suggestive of unrelated periodontal/endodontic disease and/or post-endodontic surgical lesions). After applying the exclusion criteria, 193 OPGs were included in the study. These OPGs were examined by two independent observers. Patient-related information was limited only to age and gender, thus maintaining patient confidentiality. Following sample collection, radiographs were distributed by gender and age group. The OPGs used in this study were taken by a trained radiology assistant using an X-ray generator (PM 2002 CC Proline, Planmeca, Helsinki, Finland) and Kodak dental films (T - MATE, Kodak, New York, USA). All films were processed in a XR 24 Novamachine (Durr Dental, Bietigheim, Germany) using Durr Dental developer and fixer.
All OPGs were assessed in optimal viewing conditions where the surrounding (environmental) lighting was controllable to achieve the maximum radiographic contrast. OPGs were placed on a viewing screen and the area surrounding the OPG was blocked with a dark material to block the lateral light and improve viewing contrast. To enhance the image, magnification (3×) was used on all radiographs. Prior to evaluating the OPGs, both examiners underwent a course of calibration for the Periapical Index (PAI)  using 100 retroalveolar radiographs, as recommended by the creators of this index.
Assessment of apical periodontitis
Teeth were categorized as endodontically treated if they had been obturated with a radio-opaque material in the pulp chamber and/or in one or more of the root canals. Radiographs were assessed for the presence and severity of AP using the method of Orstavik et al (1986) . Briefly, apical periodontitis was judged present in teeth in which the apical part of the periodontal space was less than twice the remaining lateral ligamental space and in which a radiolucency of more than twice the width of the lateral periodontal ligament space was associated with the apical portion of the root. Apical status was assessed using the PAI score , according to which 5 scores were attributed to the apical area of the radiographic images, as follows: 1) normal periapical structures; 2) small changes in bone structure; 3) changes in the bone structure with little mineral loss; 4) periodontitis with well-defined radiolucent area; 5) severe periodontitis with exacerbating features.
For multirooted teeth, the root with the highest PAI score was recorded. For teeth scored 3, 4 and 5, i.e., those with chronic apical periodontitis, the abbreviation "AP" was used. For teeth with AP associated with endodontic treatment, the abbreviation "AP/ET" was used.
Assessment of endodontic treatment of teeth
The criteria used for evaluation of the quality of the root filling were modified slightly from those described by Tronstad et al.  and Tavares et al. , as follows: 1. Adequate: all canals obturated, no voids present, root canal fillings terminate 0-2 mm short of the radiographic apex. 2. Inadequate: root canal fillings end > 2 mm short of the radiographic apex or are grossly overfilled (i.e. extrusion of filling material through apex), root canal fillings with voids, inadequate density, unfilled canals, and/or poor compaction.
Statistical evaluation of the data was performed using the statistical package, InStat 3 (GraphPad, San Diego, USA; demonstration version, publicly available to download at http://www.graphpad.com/demos/). The Chi-square test was used to determine the significance of differences by sex, age, dental arch (maxillary/mandibular) and region for the following parameters: number of teeth with AP; number of endodontically treated teeth; and the number of endodontically treated teeth with AP. P < 0.05 was accepted as statistically significant.
The inter-examiner agreement was determined by the Cohen's Kappa for the scores of all teeth (kappa = 0.88).
Distribution of patients by age group and sex
Distribution of total number of teeth, teeth with AP, ET, AP/ET by sex
No of teeth
Teeth with AP (%)
Teeth with ET (%)*
Teeth w. AP/ET (%)
Distribution of total number of teeth, teeth with AP, ET and AP/ET according to the age group
No of teeth
Teeth with AP (%)
Teeth with ET (%)*
Teeth w. AP/ET (%)**
Distribution of total number of teeth, teeth with AP, ET and AP/ET regarding the region
No of teeth
Teeth with AP (%)
Teeth with ET (%)
Teeth w. AP/ET (%)
Distribution of total number of teeth, teeth with AP, ET and AP/ET regarding the jaw
No of teeth
Teeth with AP (%)
Teeth with ET (%)*
Teeth w. AP/ET (%)
Quality of root filled teeth and the relation to the periapical status, percentage for healthy/diseased
Root filled teeth
The findings of this study demonstrate that AP is more prevalent in the surveyed Kosovar population (12.3%) than in other populations [9, 10, 19, 20, 25]. This result could arise for a number of reasons. First, the oral status of Kosovar adults is unsatisfactory, due to insufficient oral hygiene leading to a large numbers of carious teeth, and/or inadequate quality of fixed dentures. Second, socioeconomic factors may have a role in oral hygiene and, third, the absence of programs for integrated prevention and control of dental caries could exacerbate these problems and lead to more advanced dental and periodontal problems.
In this study, the total percentage of endodontically treated teeth was 2.3%, which is low compared with the results of some other studies [10, 11, 26, 29], in which the range was between 6.8 and 18.5%. This could be a consequence of the survey population being unrepresentative of the whole country and/or to differences in the socio-economic factors and the provision of dental care services in these various other countries. In contrast, our data are in agreement with a number of previous studies that found the prevalence of endodontically treated teeth to range between 1.3 and 4.8% [9, 13, 19, 21, 22, 25, 30].
The results of our study showed that the prevalence of AP in endodontically treated teeth is 46.3%. This prevalence was lower than that reported in Spain (64.5%)  but remain considerably higher than that reported in Portugal (22%) , Ireland (25%) , the United States (31.3%) , France (31.5%) . The high rate of AP in endodontically teeth may be the result of inadequate endodontic treatment provided by general dentists in Kosovo (and Spain).
We have also shown an age-related increase in the frequency of AP-affected teeth (Table 3), with prevalence being highest in the older groups. Other studies have also demonstrated that the prevalence of AP increases with age [5, 20, 25, 31, 32]. Younger people tend to visit the dentist more often compared with the elderly, and thus have a lower incidence of caries and periodontal diseases. There was no significant association of gender with the frequency of either AP alone or AP in endodontically treated teeth, in agreement with the findings of previous studies [5, 25, 26, 33–36].
When sub-divided by whether the teeth are mandibular or maxillary, our data regarding the frequency of AP and endodontically treated teeth are comparable with those of other studies . These studies found no difference between the maxilla and the mandible in the average percentage of teeth with AP, yet the percentage of endodontically treated maxillary teeth was twice that of endodontically treated mandibular teeth. However, the incidence of AP in maxillary teeth was found to be almost twice that in the mandible [11, 20, 25, 26, 36, 38].
Regarding the anterior/posterior region, there was no significant difference in the prevalence of AP, but endodontic treatment of posterior teeth was associated with significantly more AP than the same treatments in anterior teeth (Table 4), in agreement with previous studies [25, 36].
The prevalence of AP was influenced by the quality of the root filling. The measurement and categorization of the quality of the root filling differs among studies. Some studies use only length for determining technical quality [10, 19, 39]. Other studies have used both length and adequate seal, either reporting both parameters individually  or combining the length and seal into a single amalgamated value . Petersson et al. reported only on complete/incomplete obturation and whether there was any evidence of overfilling . In our study, the criteria used for the evaluation of the quality of root filling were modified slightly from those described by Tronstad et al.  and Tavares et al. .
The quality of the root filling was frequently unsatisfactory. AP was present in 46.3% of endodontically treated teeth. Only 30.5% of the root filled teeth fulfilled the criteria for an acceptable root canal filling, which is low compared with other studies [10, 12, 19, 20, 22, 30]. Although the methods/parameters used to evaluate the quality of root canal filling were not the same as other studies, we are confident that the poor quality of root canal filling observed in our study are the result of low standards and/or poor technique in root canal procedures. This situation arises because, in Kosovo, endodontic treatment is performed by general dentists; endodontic specialists with additional training and expertise could raise the general standard of root canal treatments but there are currently very few practicing dentists with these skills in Kosovo.
Continuing medical education efforts to train future and current dental practitioners, extended support for programs in caries control and prevention, and general improvement in the socio-economic status of the population would make a significant contribution to reducing the prevalence of AP associated with endodontic treatment in the population of Kosovo. Further studies of dental health involving larger samples that cover more regions of Kosovo will help to identify public dental health problems, an essential step in improving the general health status of the citizens of this country.
The authors wish to acknowledge the help and advice provided by professor Orstavik D.
- Siqueira JF, Rocas IN: Bacterial pathogenesis and mediators in apical periodontitis. Braz Dent J. 2007, 18 (4): 267-280. 10.1590/S0103-64402007000400001.View ArticlePubMed
- Kakehashi S, Stanley HR, Fitzgerald RJ: The effects of surgical exposure of dental pulps in germ-free and convencional laboratory rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1965, 20: 340-349.View Article
- Moller AJ, Fabricius L, Dahlen G, Sundqvist G, Happonen RP: Apical periodontitis development and bacterial response to endodontic treatment. Experimental root canal infections in monkeys with selected bacterial strains. Eur J Oral Sci. 2004, 112: 207-215. 10.1111/j.1600-0722.2004.00135.x.View ArticlePubMed
- Kirkevang LL, Vaeth M, Horsted-Bindslev P, Bahrami G, Wenzel A: Risk factors for developing apical periodontitis in a general population. Int Endod J. 2007, 40: 290-299. 10.1111/j.1365-2591.2007.01224.x.View ArticlePubMed
- Al-Omari MA, Hazaa A, Haddad F: Frequency and distribution of root filled teeth and apical periodontitis in a Jordanian subpopulation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011, 111 (1): e59-65. 10.1016/j.tripleo.2010.08.007.View ArticlePubMed
- Kabak Y, Abbott PV: Prevalence of apical periodontitis and the quality of endodontic treatment in an adult Belarusian population. Int Endod J. 2005, 38 (4): 238-245. 10.1111/j.1365-2591.2005.00942.x.View ArticlePubMed
- Abbott PV: The periapical space--a dynamic interface. Aust Endod J. 2002, 28 (3): 96-107. 10.1111/j.1747-4477.2002.tb00399.x.View ArticlePubMed
- Nair PN: Pathogenesis of apical periodontitis and the causes of endodontic failures. Crit Rev Oral Biol Med. 2004, 15 (6): 348-381. 10.1177/154411130401500604.View ArticlePubMed
- Dugas NN, Lawrence HP, Teplitsky PE, Pharoah MJ, Friedman S: Periapical health and treatment quality assessment of root-filled teeth in two Canadian populations. Int Endod J. 2003, 36 (3): 181-192. 10.1046/j.1365-2591.2003.00640.x.View ArticlePubMed
- De Moor RJ, Hommez GM, De Boever JG, Delme KI, Martens GE: Periapical health related to the quality of root canal treatment in a Belgian population. Int Endod J. 2000, 33 (2): 113-120. 10.1046/j.1365-2591.2000.00295.x.View ArticlePubMed
- Lupi-Pegurier L, Bertrand MF, Muller-Bolla M, Rocca JP, Bolla M: Periapical status, prevalence and quality of endodontic treatment in an adult French population. Int Endod J. 2002, 35 (8): 690-697. 10.1046/j.1365-2591.2002.00547.x.View ArticlePubMed
- Odesjo B, Hellden L, Salonen L, Langeland K: Prevalence of previous endodontic treatment, technical standard and occurrence of periapical lesions in a randomly selected adult, general population. Endod Dent Traumatol. 1990, 6 (6): 265-272. 10.1111/j.1600-9657.1990.tb00430.x.View ArticlePubMed
- Kirkevang LL, Orstavik D, Horsted-Bindslev P, Wenzel A: Periapical status and quality of root fillings and coronal restorations in a Danish population. Int Endod J. 2000, 33 (6): 509-515. 10.1046/j.1365-2591.2000.00381.x.View ArticlePubMed
- Molven O, Halse A, Fristad I: Long-term reliability and observer comparisons in the radiographic diagnosis of periapical disease. Int Endod J. 2002, 35 (2): 142-147. 10.1046/j.0143-2885.2001.00525.x.View ArticlePubMed
- Huumonen S, Orstavik D: Radiological aspects of apical periodontits. Endodontic Topics. 2002, 1: 3-25. 10.1034/j.1601-1546.2002.10102.x.View Article
- Estrela C, Leles CR, Hollanda AC, Moura MS, Pecora JD: Prevalence and risk factors of apical periodontitis in endodontically treated teeth in a selected population of Brazilian adults. Braz Dent J. 2008, 19 (1): 34-39. 10.1590/S0103-64402008000100006.View ArticlePubMed
- Orstavik D, Kerekes K, Eriksen HM: The periapical index: a scoring system for rediographic assessment of apical periodontitis. Endod Dent Traumatol. 1986, 2 (20-34):
- Nair PN, Sjogren U, Figdor D, Sundqvist G: Persistent periapical radiolucencies of root-filled human teeth, failed endodontic treatments, and periapical scars. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999, 87 (5): 617-627. 10.1016/S1079-2104(99)70145-9.View ArticlePubMed
- De Cleen MJ, Schuurs AH, Wesselink PR, Wu MK: Periapical status and prevalence of endodontic treatment in an adult Dutch population. Int Endod J. 1993, 26 (2): 112-119. 10.1111/j.1365-2591.1993.tb00552.x.View ArticlePubMed
- Buckley M, Spangberg LS: The prevalence and technical quality of endodontic treatment in an American subpopulation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995, 79 (1): 92-100. 10.1016/S1079-2104(05)80081-2.View ArticlePubMed
- Eriksen HM, Berset GP, Hansen BF, Bjertness E: Changes in endodontic status 1973-1993 among 35-year-olds in Oslo, Norway. Int Endod J. 1995, 28 (3): 129-132. 10.1111/j.1365-2591.1995.tb00286.x.View ArticlePubMed
- Weiger R, Hitzler S, Hermle G, Lost C: Periapical status, quality of root canal fillings and estimated endodontic treatment needs in an urban German population. Endod Dent Traumatol. 1997, 13 (2): 69-74. 10.1111/j.1600-9657.1997.tb00013.x.View ArticlePubMed
- Kirkevang LL, Horsted-Bindslev P, Orstavik D, Wenzel A: Frequency and distribution of endodontically treated teeth and apical periodontitis in an urban Danish population. Int Endod J. 2001, 34 (3): 198-205. 10.1046/j.1365-2591.2001.00370.x.View ArticlePubMed
- Loftus JJ, Keating AP, McCartan BE: Periapical status and quality of endodontic treatment in an adult Irish population. Int Endod J. 2005, 38 (2): 81-86. 10.1111/j.1365-2591.2004.00902.x.View ArticlePubMed
- Jimenez-Pinzon A, Segura-Egea JJ, Poyato-Ferrera M, Velasco-Ortega E, Rios-Santos JV: Prevalence of apical periodontitis and frequency of root-filled teeth in an adult Spanish population. Int Endod J. 2004, 37 (3): 167-173. 10.1111/j.0143-2885.2004.00759.x.View ArticlePubMed
- Tercas AG, de Oliveira AE, Lopes FF, Maia Filho EM: Radiographic study of the prevalence of apical periodontitis and endodontic treatment in the adult population of Sao Luis, MA, Brazil. J Appl Oral Sci. 2006, 14 (3): 183-187. 10.1590/S1678-77572006000300007.PubMed CentralView ArticlePubMed
- Tronstad L, Asbjornsen K, Doving L, Pedersen I, Eriksen HM: Influence of coronal restorations on the periapical health of endodontically treated teeth. Endod Dent Traumatol. 2000, 16 (5): 218-221. 10.1034/j.1600-9657.2000.016005218.x.View ArticlePubMed
- Tavares PB, Bonte E, Boukpessi T, Siqueira JF, Lasfargues JJ: Prevalence of apical periodontitis in root canal-treated teeth from an urban French population: influence of the quality of root canal fillings and coronal restorations. J Endod. 2009, 35 (6): 810-813. 10.1016/j.joen.2009.03.048.View ArticlePubMed
- Gencoglu N, Pekiner FN, Gumru B, Helvacioglu D: Periapical status and quality of root fillings and coronal restorations in an adult Turkish subpopulation. Eur J Dent. 2010, 4 (1): 17-22.PubMed CentralPubMed
- Marques MD, Moreira B, Eriksen HM: Prevalence of apical periodontitis and results of endodontic treatment in an adult, Portuguese population. Int Endod J. 1998, 31 (3): 161-165.View ArticlePubMed
- Eriksen HM: Epidemiology of apical periodontitis. Essential Endodontology. Edited by: Orstavik D, Pitt Ford TR. 1998, London: Blackwell Science, LTD, 179-191. 2
- Kirkevang LL: Periapical endodontic status in Danish populations. 2001, University of Arhus
- Chugal NM, Clive JM, Spangberg LS: A prognostic model for assessment of the outcome of endodontic treatment: Effect of biologic and diagnostic variables. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001, 91 (3): 342-352. 10.1067/moe.2001.113106.View ArticlePubMed
- Dammaschke T, Steven D, Kaup M, Ott KH: Long-term survival of root-canal-treated teeth: a retrospective study over 10 years. J Endod. 2003, 29 (10): 638-643. 10.1097/00004770-200310000-00006.View ArticlePubMed
- Orstavik D, Qvist V, Stoltze K: A multivariate analysis of the outcome of endodontic treatment. Eur J Oral Sci. 2004, 112 (3): 224-230. 10.1111/j.1600-0722.2004.00122.x.View ArticlePubMed
- Georgopoulou MK, Spanaki-Voreadi AP, Pantazis N, Kontakiotis EG: Frequency and distribution of root filled teeth and apical periodontitis in a Greek population. Int Endod J. 2005, 38 (2): 105-111. 10.1111/j.1365-2591.2004.00907.x.View ArticlePubMed
- Allard U, Palmqvist S: A radiographic survey of periapical conditions in elderly people in a Swedish county population. Endod Dent Traumatol. 1986, 2 (3): 103-108. 10.1111/j.1600-9657.1986.tb00135.x.View ArticlePubMed
- Spatafore CM, Griffin JA, Keyes GG, Wearden S, Skidmore AE: Periapical biopsy report: an analysis of over a 10-year period. J Endod. 1990, 16 (5): 239-241. 10.1016/S0099-2399(06)81679-1.View ArticlePubMed
- Saunders WP, Saunders EM, Sadiq J, Cruickshank E: Technical standard of root canal treatment in an adult Scottish sub-population. Br Dent J. 1997, 182 (10): 382-386. 10.1038/sj.bdj.4809394.View ArticlePubMed
- Petersson K, Petersson A, Olsson B, Hakansson J, Wennberg A: Technical quality of root fillings in an adult Swedish population. Endod Dent Traumatol. 1986, 2 (3): 99-102. 10.1111/j.1600-9657.1986.tb00134.x.View ArticlePubMed
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6831/11/32/prepub
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