Table 3 Antifungal susceptibility profile, against amphotericin B, flucytosine, fluconazole, miconazole, itraconazole, and micafungin, of Candida species isolated from patients with oral candidiasis in the 2006–2007 and 2012–2013 studies

2006-2007

C. albicans

56

8

43

3

2

0.5

0.5

C. glabrata

8

1

2

2

2

1

0.5

2

C. tropicalis

1

1

0.25

0.25

2012-2013

C. albicans

112

4

12

86

9

1

0.5

1

C. glabrata

36

1

2

16

14

2

1

0.5

1

C. tropicalis

3

1

2

1

1

C. parapsilosis

2

2

<0.03

<0.03

C. krusei

1

1

0.5

0.5

b. flucytosine (5-FC)

Year

Strain

No. of strains

MIC (μg/mL)

MIC ₅₀

MIC ₉₀

<0.125

0.125

0.25

0.5

1

2

4

8

16

32

64

>64

2006-2007

C. albicans

56

18

8

24

3

1

2

0.25

0.5

C. glabrata

8

4

1

1

2

<0.125

16

C. tropicalis

1

1

0.125

0.125

2012-2013

C. albicans

112

56

1

43

3

3

4

1

1

0.25

1

C. glabrata

36

20

6

6

2

1

1

<0.125

8

C. tropicalis

3

3

<0.125

<0.125

C. parapsilosis

2

2

2

C. krusei

1

1

1

0.25

0.25

c. fluconazole (FLCZ)

Year

Strain

No. of strains

MIC (μg/mL)

MIC ₅₀

MIC ₉₀

<0.125

0.125

0.25

0.5

1

2

4

8

16

32

64

>64

2006-2007

C. albicans

56

22

22

5

1

1

1

1

3

0.5

4

C. glabrata

8

1

2

2

1

1

1

2

>64

C. tropicalis

1

1

>64

>64

2012-2013

C. albicans

112

4

33

51

2

1

3

3

3

0.5

2

C. glabrata

36

4

1

5

6

7

7

2

16

64

C. tropicalis

3

1

2

32

32

C. parapsilosis

2

2

2

2

C. krusei

1

1

2

2

d. miconazole (MCZ)

Year

Strain

No. of strains

MIC (μg/mL)

MIC ₅₀

MIC ₉₀

<0.03

0.03

0.06

0.125

0.25

0.5

1

2

4

8

16

>16

2006-2007

C. albicans

56

2

22

20

8

1

3

0.125

0.25

C. glabrata

8

1

2

2

1

2

1

4

C. tropicalis

1

0.125

0.125

2012-2013

C. albicans

112

2

20

64

18

1

1

1

2

3

0.25

0.5

C. glabrata

36

1

5

12

7

3

3

2

3

2

16

C. tropicalis

3

1

1

1

1

4

C. parapsilosis

2

1

1

1-2

2

C. kurusei

1

1

4

4

e. itraconazole (ITCZ)

Year

Strain

No. of strains

MIC (μg/mL)

MIC ₅₀

MIC ₉₀

<0.015

0.015

0.03

0.06

0.125

0.25

0.5

1

2

4

8

>8

2006-2007

C. albicans

56

4

20

14

9

2

1

3

1

2

0.06

1

C. glabrata

8

1

1

1

1

1

1

2

0.05

>8

C. tropicalis

1

>8

>8

2012-2013

C. albicans

112

2

12

34

50

5

4

1

1

3

0.125

0.25

C. glabrata

36

1

3

3

5

9

8

2

5

1

>8

C. tropicalis

3

1

1

1

1

2

C. parapsilosis

2

1

1

0.25

0.25

C. kurusei

1

1

0.5

0.5

f. micafungin (MCFG)

Year

Strain

No.of strains

MIC (μg/mL)

MIC ₅₀

MIC ₉₀

<0.03

0.03

0.06

0.125

0.25

0.5

1

2

4

8

16

>16

2006-2007

C. albicans

56

32

9

13

1

1

<0.03

0.06

C. glabrata

8

1

2

2

1

1

1

0.125

>16

C. tropicalis

1

1

0.06

0.06

2012-2013

C. albicans

112

95

12

2

1

1

1

<0.03

0.06

C. glabrata

36

16

1

1

3

5

6

1

2

1

0.125

1

C. tropicalis

3

2

1

<0.03

00.6

C. parapsilosis

2

2

<0.03

<0.03

C. kurusei

1

0.5

0.5