Table 3 Main characteristic of the eligible studies for the periodontitis treatment and dyslipidemia
Author, year | Country | Study design | Sample size (treat / control) | Diagnosis criteria for periodontitis | Mean age (year) | Age ratio (treat: control) | % Males | Male ratio (treat: control) | Therapeutic Schedule | Dyslipidemia diagnosis (any of the following indicators, mg/dl) | Lipids index | Effect index | Matching or correction factor | Quality |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Duan JY, 2009 [67] | China | Cohort (prospective) | 20 | Secure | 55.60 | NI | 55 | NI | Initial therapy | TC > 220; TG > 150; HDL < 35; LDL > 140 | TC, TG, LDL, HDL | Mean (SD) | – | High |
Fentoglu O, 2010 [68] | Turkey | Cohort (prospective) | 20 | Insecure | 51.85 | NI | 40 | NI | Initial therapy | TG > 200; TC > 200; LDL > 130; HDL < 35; VLDL > 40 | TG, TC, LDL, HDL | Mean (SD) | – | High |
Fu YW, 2016 [69] | Chnia | RCT | 54/55 | Secure | 46.93 | 0.99 |  |  | Treat group: Initial therapy; Control group: supragingival scaling | TG > 20; HDL < 40; LDL > 160 | TC, TG, LDL, HDL | Mean (SD) | – | High risk of bias |
Losche W, 2005 [70] | Germany | Cohort (prospective) | 32 | NI | 42.80 | NI | 53.13 | NI | Initial therapy | NI | TC, TG, LDL, HDL | Mean (SD) | – | Moderate |
Macovei-Surdu A, 2013 [71] | Romania | Cohort (prospective) | 30/30 | Insecure | 39.53 | 0.96 | 60 | 1.36 | Treat group: Initial therapy: Control group: oral hygiene maintenance measures | NI | TC, TG, LDL, HDL | Mean | – | Moderate |
Nassar PO, 2012 [72] | Brazil | RCT | 10/10 | Secure | NI | NI | NI | NI | Treat group: Initial therapy, Maintenance therapy: Control group: Initial therapy | NI | TC, TG | Mean (SD) | – | Unclear risk of bias |
Nibali L, 2015 [101] | United Kingdom | Cohort (prospective) | 12 | Secure | NI | NI | NI | NI | Initial therapy, open flap debridement | Â | LDL, HDL, IDL, VLDL | Mean (SD) | Age, gender and number of teeth | High |
Nicolaiciuc O, 2016 [74] | Romania | Cohort (prospective) | 20 | Insecure | 49.55 | NI | 40 | NI | Initial therapy | TG > 200; TC > 200; LDL > 130; HDL < 35; VLDL > 40 | TG, TC, LDL, HDL, VLDL | Mean (SD) | – | Moderate |
Oz SG, 2007 [75] | Turkey | RCT | 25/25 | Insecure | 50.34 | 0.95 | 38 | 1.11 | Treat group: Initial therapy: Control group: without applying periodontal treatment | TC>200; LDL>130; HDL<35; VLDL> 40; TG>200 | TG, TC, LDL, HDL, VLDL | Mean (SD) | – | Unclear risk of bias |
Tawfig A, 2015 [76] | Saudi Arabia | RCT | 15/15 | Insecure | NI | NI | 63.33 | 1.38 | Treat group: Initial therapy, oral hygiene instructions, Control group: oral hygiene instructions | TC ≥200; LDL ≥130; HDL ≤35; TG ≥150 | TC, TG, LDL, HDL | Mean (SD) | – | Unclear risk of bias |
Zuza EP, 2016 [77] | Brazil | Cohort (prospective) | 54 | Secure | 44.26 | NI | 25.93 | NI | Initial therapy | NI | TC, TG, LDL, HDL | Mean (SD) | – | High |
Abhay Pandurang Kolte, 2022 [78] | India | Intervention trial | 60 | Secure | NI | NI | 36.67 | NI | Non-surgical periodontal treatment | NI | TC, TG, LDL, HDL | Mean (SD) | – | – |