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Figure 2 | BMC Oral Health

Figure 2

From: Design of a randomized controlled double-blind crossover clinical trial to assess the effects of saliva substitutes on bovine enamel and dentin in situ

Figure 2

Study design. t0: - Integration of specimens into removable (partial) dentures Covering of reference areas/sound surfaces of specimens - Issue of study medication (blinded) - Anamnesis and oral findings - Measurement of unstimulated saliva flow rate - First questionnaire. t5: - Covering of effect areas after five weeks - Measurement of unstimulated whole saliva. t7: - Removal of specimens from the dentures - Measurement of unstimulated saliva flowrate - Second questionnaire - Collecting of spray bottles. t8: - Integration of specimens into the removable (partial) dentures - Covering of the reference areas/sound surfaces of specimens - Issue of study medication (blinded) - Anamnesis and oral findings - Measurement of unstimulated saliva flowrate - Third questionnaire. t13: - Covering of effect fields after five weeks - Measurement of unstimulated saliva flowrate. t15: - Removal of specimens from dentures; repair of dentures - Measurement of unstimulated saliva flowrate - Last questionnaire - Collecting of spray bottles

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