From: A systematic review of methods to diagnose oral dryness and salivary gland function
First author, year of publication | Study population | Control group |
---|---|---|
Al-Hashimi 1998 [31] | 43 subjects: | 39 age/gender/race matched healthy control subjects |
−38 with pSSa | ||
−5 with sSSb | ||
Age and gender not stated | ||
Almståhl 2003 [32] | 39 subjects: | 12 control subjects |
−9 subjects with history of head and neck radiation | (10 females/2 males) with normal salivary secretion rates Mean age 54 yrs | |
(2 females/8 malesc) | ||
Mean age 55 yrs | ||
−10 subjects with pSS | ||
(10 females) | ||
Mean age 57 yrs | ||
−10 subjects treated with neuroleptic injections | ||
(4 females/6 males) | ||
Mean age 44 yrs | ||
–10 subjects with hyposalivation due to medication or unknown origin | ||
(9 females/1 male) | ||
Mean age 54 yrs | ||
El-Miedany 1999 [33] | 25 subjects: | 15 healthy age-matched controls |
−15 with pSS | Mean age 50 yrs | |
−10 with sSS | 10 younger controls | |
(20 females/5 males) | Mean age 26.2 yrs | |
Mean age 48 yrs | Gender not stated | |
Håkansson 1994 [34] | 17 subjects with pSS (15 females/2 males) | 30 subjects with symptoms of dry mouth and/or eyes |
Mean age 63 yrs | (21 females/9 males) | |
Mean age 69 yrs | ||
12 subjects without symptoms of dry mouth and/or eyes | ||
(6 females/6 males) | ||
Mean age 68 yrs | ||
Hay 1998 [35] | 341 subjects: | |
−189 females | ||
Age (median) 49 yrs | ||
−152 males | ||
Age (median) 46 yrs | ||
First author, year of publication | Study population | Control group |
Kalk 2001 [36] | 100 consecutive subjects: | 36 healthy subjects |
−33 with pSS | (20 females/16 males) | |
(30 females/3 males) | Mean age 39 yrs | |
Mean age 51 yrs | ||
−25 with sSS | ||
(21 females/4 males) | ||
Mean age 54 yrs | ||
−42 tested negative for SS | ||
(40 females/2 males) | ||
Mean age 55 yrs | ||
Kalk 2002 [37] | 20 subjects: | 100 subjects (from previous study reported above-see study population) |
−2 with pSS | ||
−5 with sSS | ||
(6 females/1 male) | ||
Mean age 62 yrs | ||
−13 non-SS | ||
(13 females) | ||
Mean age 55 yrs | ||
Kanehira 2009 [38] | 9 subjects with complaints of decreased salivary flow rate | 31 healthy subjects |
Age and gender reported for all included subjects | ||
(22 females/19 males) | ||
Mean age 48.8 yrs | ||
Kohn 1992 [39] | 22 subjects: | 33 healthy volunteers |
−19 with pSS | (20 females/13 males) | |
−1 with sSS | Mean age 54.4 yrs | |
−2 with idiopathic xerostomia | ||
(17 females/5 males) | ||
Mean age 52.2 yrs | ||
Lee 2002 [40] | 20 subjects with dry mouth | 20 age/gender matched healthy control subjects |
(unstimulated whole saliva flow rate <0.15 ml/min) | (18 females/2 males) | |
(18 females/2 males) | Mean age 42.6 yrs | |
Mean age 43.6 yrs | ||
First author, year of publication | Study population | Control group |
López-Jornet 2006 [41] | 92 subjects: | 70 healthy volunteers |
−61 with pSS or sSS | (35 females/35 males) | |
(50 females/11 males) | Mean age 40.53 yrs | |
Mean age 57.08 yrs | ||
−31 displaying symptoms of oral dryness from different causes | ||
(29 females/2 males) | ||
Mean age 52.52 yrs | ||
Navazesh 1992 [42] | A total of 71 subjects were included. | Unclear |
Approx. half with salivary gland hypofunction, defined as unstimulated whole salivary flow rate ≤0.20 ml/min | Approx. half of the total number of included subjects. Individuals with normal salivary flow rates. | |
(48 females/23 males) | ||
Mean age 52 yrs | ||
Pedersen 1999 [43] | 16 subjects: | 14 healthy volunteers |
(14 females/2 males) meeting the 1993 European classification for pSS. | (13 females/1 male) | |
Mean age unclear | Mean age 50 yrs | |
13 healthy volunteers | ||
(12 females/1 male) | ||
Mean age 24 yrs | ||
Pennec 1993 [44] | 72 consecutive subjects: | 14 healthy subjects |
- 40 subjects with pSS | Mean age 64.7 yrs | |
−16 subjects with sSS | Gender not stated | |
−16 subjects with connective tissue disease but no evidence of sSS | ||
(70 females/2males) | ||
Mean age 59.4 yrs | ||
Sánchez-Guerrero 2002 [45] | 90 subjects: | 152 healthy subjects |
−30 subjects with pSS | (106 females/46 males) | |
(29 females/1 male) | Mean age 35.2 yrs | |
Mean age 50.6 yrs | ||
−60 subjects with CTDs without SS | ||
(50 females/10 males) | ||
Mean age 37.4 yrs | ||
First author, year of publication | Study population | Control group |
Sreebny 1988 [4] | 151 subjects with reported dry mouth | 372 subjects without reported dry mouth |
(109 females/42 males) | (219 females/159 males) | |
Age range 18–55+ | Age range 18–55+ | |
Wolff 1998 [46] | 50 subjects: | 25 subjects with no perception of dry mouth and no medication with resting salivary flow rates > 1.0 ml/min |
−25 subjects with complaints of ‘dry mouth’ due to medication, with resting salivary flow rates ≤0.1 ml/min | (15 females/10 males) Mean age 44 | |
(20 females/5 males) | ||
Mean age 48.5 | ||
−25 subjects with complaints of ‘dry mouth’ due to medication, with resting salivary flow rates > 0.1 ml/min | ||
(18/females/7 males) | ||
Mean age 49.2 | ||
Wolff 2002 [47] | 27 subjects with complaints of dry mouth | 32 healthy subjects |
Age and gender not stated | Age and gender not stated |