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Table 1 Body weight, amount of diammine silver fluoride (DSF) applied, fluoride dose, and serum fluoride pharmacokinetics in treatment of dentin hypersensitivity in adults

From: Short term serum pharmacokinetics of diammine silver fluoride after oral application

Subject

Body weight (kg)

Weight of DSF solution applied (mg)

Calculated volume of DSF solution applied (μL)a

Calculated fluoride applied (mg)b

Fluoride - oral RfDcNOAELdfor subject (mg)e

Time to maximum serum concentration (h)

Maximum serum fluoride (μmol/L)

1

48

3.8

3.03

0.17

2.88

3.0

1.46

2

54

8.2

6.54

0.36

3.24

3.2

2.88

3

84

5.8

4.63

0.25

5.04

4.0

1.02

4

82

7.6

6.07

0.33

4.92

3.0

2.77

5

54

11.9

9.50

0.52

3.24

1.0

1.56

6

56

8.1

6.46

0.36

3.36

4.0

1.45

  1. aCalculated based on Specific Gravity of 1.253.
  2. bCalculated based on volume of DSF solution applied times 0.055 mg/μL.
  3. cRfD = U.S. Environmental Protection Agency oral reference dose.
  4. dNOAEL = no observable adverse effect level.
  5. eCalculated based on subject weight (kg) times NOAEL of 0.06 mg/(kg d).