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Table 2 Silver dose and serum silver pharmacokinetics after application of diammine silver fluoride topically

From: Short term serum pharmacokinetics of diammine silver fluoride after oral application

Subject

Silver applied (mg)a

Silver - RfDbNOAELcfor subject (mg)d

Time to maximum serum concentration (h)

Maximum serum silver (nmol/L)

1

0.75

0.24

2.0

28

2

1.63

0.27

2.1

269

3

1.15

0.42

4.0

250

4

1.51

0.41

3.0

213

5

2.37

0.27

1.0

269

6

1.61

0.28

3.0

204

  1. aCalculated based on volume of DSF solution applied times 0.249 mg/μL.
  2. bRfD = U.S. Environmental Protection Agency oral reference dose.
  3. c NOAEL = no observable adverse effect level.
  4. dCalculated based on subject weight (kg) times NOAEL RfD of 0.005 mg/(kg d).