Myelosuppression grading of chemotherapies for hematologic malignancies to facilitate communication between medical and dental staff: lessons from two cases experienced odontogenic septicemia

Table 1 Myelosuppression grading of chemotherapies for hematologic malignancies

Myelosuppression grading
Grade A	mild myelosuppression
Grade B	moderate myelosuppression (2–3 weeks for bone marrow recovery)
Grade C	severe myelosuppression (4 weeks for bone marrow recovery)
Grade D	severe myelosuppression and persistent immunodeficiency
Regimens
Grade B	Consolidation therapy for leukemia:
	DA (DNR, Ara-C); MA (MIT, Ara-C); high-dose Ara-C
	Chemotherapy for Malignant lymphoma:
	ABVD (ADR, BLM, VLB, DTIC); CHOP (CPA, ADR, VCR, PSL); ESHAP (ETP, Ara-C, CDDP, mPSL); Hyper-CVAD/MA (course 1: CPA, VCR, ADR, DEX, course 2: MTX, Ara-C, mPSL)
Grade C	Remission induction therapy for acute leukemia:
	ATRA, IDR, Ara-C; DCM (DNR, Ara-C, 6-MP); DNR, VCR, CPA, L-Asp, PSL; HAM (high dose Ara-C, MIT); IDR, Ara-C
	High - dose chemotherapy with peripheral blood stem cell harvest:
	high dose VP-16
	Salvage chemotherapy for T-cell lymphoma:
	SMILE (MTX, ETP, IFM, L-Asp, DEX)
Grade D	Conditioning regimen for transplant:
Grade D	MCVC (MCNU, CBDCA, ETP, CPA); HD-ICE (IFM, CBCDA, VP-16); Flu/BU; Flu/Mel/TBI; TBI/CY

ADR adriamycin, Ara-C cytarabine, BLM bleomycin, BU Busulfan, CBDCA carboplatin, CDDP cisplatin, CPA/CY cyclophosphamide, DEX dexamethasone, DNR daunorubicin, DTIC dacarbazine, ETP/VP-16 etoposide, Flu fludarabine, IDR idarubicin, IFM ifosfamide, L-Asp L-asparaginase, MCNU ranimustine, Mel melphalan, MIT mitoxantrone, mPSL methylprednisolone, MTX methotrexate, PSL prednisolone, TBI total body irradiation, VCR vincristine, VLB vinblastine, 6-MP 6-mercaptopurine.

ISSN: 1472-6831