Genome wide association scan for chronic periodontitis implicates novel locus

BMC Oral Health

Table 2 Summary of the results of the genome wide association scans and independent analysis for chronic periodontitis

Marker	Minor allele frequency	Locus	Location/gene	Genome wide scan p-value all samples (99 affected, 767 unaffected)	Genome wide scan p-value whites only (63 affected, 543 unaffected)	Independent Porto Alegre cohort p-value (430 affected, 1,030 unaffected)	Independent Rio de Janeiro cohort p-value (183 affected, 176 unaffected)
rs10858049	0.19	1p13.2	DENND2C	9.54E-05	0.01	0.78	0.3
rs4572866	0.19	4p15.2	Intergenic	5.80E-05	0.0006	0.49	0.42
rs6905786	0.45	6q16.2	Intergenic	1.41E-05	0.0003	0.65	0.72
rs7740539	0.26	6q21	Intergenic	1.39E-05	2.85E-05	0.16	0.65
rs10266202	0.41	7p21.3	Intergenic	3.89E-05	0.0003	0.68	0.4
rs4735081	0.4	8q23.1	Intergenic	1.80E-05	4.71E-05	0.48	0.86
rs6597536	0.15	9q34.13	MED27	3.62E-05	0.0002	0.91	0.9
rs1954179	0.34	10q25.2	RBM20	7.42E-05	0.0008	0.85	0.82
rs10501568	0.1	11p14.1	DLG2	8.81E-06	9.38E-05	0.58	0.66
rs1026477	0.47	11p14.1	MPPED2	5.48E-05	2.79E-06	0.68	0.98
rs982322	0.31	12q14.1	SLC16A7	3.99E-05	0.0008	0.48	0.74
rs1913208	0.42	13q33.1	Intergenic	6.46E-05	0.0004	0.17	0.6
rs1477403	0.46	16q22.3	Intergenic	6.18E-05	0.0001	0.05	0.66
rs1558878	0.45	17q24.2	ARSG	8.53E-05	0.0004	0.63	0.29
rs8066940	0.42	17q25.3	Intergenic	2.79E-05	0.0004	0.37	0.3
rs7254232	0.38	19q13.32	Intergenic	2.57E-06	0.0005	0.14	0.2
rs2833017	0.45	21q22.11	Intergenic	5.20E-05	0.0004	0.32	0.001
rs9305434	0.33	21q22.11	Intergenic	7.91E-05	0.0008	0.41	0.008
rs2048126	0.46	21q22.11	Intergenic	8.43E-05	0.0008	0.43	0.001
rs466092	0.25	21q22.3	MX2	1.28E-05	1.10E-05	0.14	0.76

Note: P-values are related to the differences in distribution of single nucleotide polymorphisms between affected and unaffected individuals.

ISSN: 1472-6831