Table 3 Pooled ORs and 95% CIs of stratified meta-analysis
From: Association between polymorphism of TGFA Taq I and cleft Lip and/or palate: a meta-analysis
Subgroup | Genotype | No of studies | Test of association | Test of heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|
OR (95% CI) | Z | P-value | Model | P-value | I2(%) | |||
Ethnicity | ||||||||
African | ||||||||
| Â | C1C2+C2C2 vs. C1C1 | 3 | 1.92 [0.63,1.90] | 1.14 | 0.253 | F | 0.754 | 0.0 |
| Â | C2 vs. C1 | 3 | 1.15 [0.50,2.66] | 0.33 | 0.741 | F | 0.254 | 26.9 |
Caucasian | ||||||||
| Â | C1C2 vs. C1C1 | 9 | 1.95 [1.34,2.86]* | 3.48 | 0.001 | R | 0.016 | 57.3 |
| Â | C2C2 vs. C1C1 | 9 | 1.50 [0.79,2.84] | 1.25 | 0.211 | F | 0.341 | 11.2 |
| Â | C1C2+C2C2 vs. C1C1 | 9 | 1.68 [1.18,2.38]* | 2.87 | 0.004 | R | 0.000 | 69.9 |
| Â | C2C2 vs. C1C2+C1C1 | 9 | 1.36 [0.71,2.58] | 0.93 | 0.354 | F | 0.443 | 0.0 |
| Â | C2 vs. C1 | 14 | 1.52 [1.14,2.02]* | 2.87 | 0.004 | R | 0.000 | 74.8 |
Hispanic | ||||||||
| Â | C1C2 vs. C1C1 | 3 | 1.02 [0.72,1.43] | 0.08 | 0.935 | F | 0.594 | 0.0 |
| Â | C2C2 vs. C1C1 | 3 | 1.44 [0.27,7.67] | 0.42 | 0.672 | F | 0.669 | 0.0 |
| Â | C1C2+C2C2 vs. C1C1 | 4 | 1.04 [0.76,1.44] | 0.27 | 0.789 | F | 0.792 | 0.0 |
| Â | C2C2 vs. C1C2+C1C1 | 3 | 1.40 [0.26,7.46] | 0.4 | 0.692 | F | 0.663 | 0.0 |
| Â | C2 vs. C1 | 3 | 1.04 [0.75,1.44] | 0.23 | 0.816 | F | 0.608 | 0.0 |
Disease | ||||||||
CP | ||||||||
| Â | C1C2 vs. C1C1 | 3 | 1.54 [1.04,2.27]* | 2.14 | 0.032 | F | 0.215 | 34.9 |
| Â | C2C2 vs. C1C1 | 3 | 1.32 [0.35,5.00] | 0.40 | 0.687 | F | 0.478 | 0.0 |
| Â | C1C2+C2C2 vs. C1C1 | 5 | 1.45 [1.10,1.91] | 2.61 | 0.009 | F | 0.281 | 21.0 |
| Â | C2C2 vs. C1C2+C1C1 | 3 | 1.26 [0.33,4.78] | 0.33 | 0.738 | F | 0.496 | 0.0 |
| Â | C2 vs. C1 | 8 | 1.38 [1.10,1.73]* | 2.82 | 0.005 | F | 0.226 | 25.4 |
CL/P | ||||||||
| Â | C1C2 vs. C1C1 | 12 | 1.60 [1.16,2.20]* | 2.89 | 0.004 | R | 0.010 | 55.7 |
| Â | C2C2 vs. C1C1 | 11 | 1.64 [0.88,3.04] | 1.57 | 0.116 | F | 0.457 | 0.0 |
| Â | C1C2+C2C2 vs. C1C1 | 11 | 1.46 [1.09,1.95]* | 2.55 | 0.011 | R | 0.001 | 62.7 |
| Â | C2C2 vs. C1C2+C1C1 | 11 | 1.45 [0.82,2.78] | 1.25 | 0.211 | F | 0.545 | 0.0 |
| Â | C2 vs. C1 | 17 | 1.29 [1.01,1.66]* | 2.03 | 0.042 | R | 0.000 | 63.1 |
Source of control | ||||||||
HB | ||||||||
| Â | C1C2 vs. C1C1 | 10 | 1.84 [1.32,2.56]* | 3.58 | 0.000 | R | 0.019 | 54.7 |
| Â | C2C2 vs. C1C1 | 10 | 2.96 [1.35,2.70]* | 4.70 | 0.000 | F | 0.965 | 0.0 |
| Â | C1C2+C2C2 vs. C1C1 | 10 | 1.99 [1.35,2.70]* | 3.66 | 0.000 | R | 0.007 | 60.1 |
| Â | C2C2 vs. C1C2+C1C1 | 10 | 2.38 [1.06,5.55]* | 5.17 | 0.000 | F | 0.968 | 0.0 |
| Â | C2 vs. C1 | 14 | 1.63 [1.22,2.18]* | 3.28 | 0.001 | R | 0.001 | 63.0 |
PB | ||||||||
| Â | C1C2+C2C2 vs. C1C1 | 3 | 0.99 [0.79,1.24] | 0.10 | 0.917 | F | 0.549 | 0.0 |
| Â | C2 vs. C1 | 3 | 1.00 [0.83,1.20] | 0.02 | 0.986 | F | 0.778 | 0.0 |