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Figure 3 | BMC Oral Health

Figure 3

From: Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model

Figure 3

P. gingivalis infection causes loss of alveolar bone volume and density as demonstrated by micro-CT. Micro-CT analysis was done four weeks after a total of eight bacterial inoculations. Decreased alveolar bone height and furcation involvement (A) and decreased mineral density at the alveolar surface (B) was noticed in the infected animals. In panel A, red arrows point to the furcation involvement. In panel B, the darker reddish-purple color indicates regions of lower mineral density. Quantification of micro-CT data shows that repetitive P. gingivalis infection caused a significant reduction in alveolar bone fraction (C), bone mineral density (D), and bone mineral content (E) compared with the controls. Abbreviations: CT, control, sham-infected; PG, P. gingivalis infected; BV/TV%, remaining alveolar bone volume over total volume; BMD, bone mineral density (normalized to hydroxyl apatite phantom); BMC, bone mineral content (=BMD X BV); *, denotes P < 0.05 compared with the controls.

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