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Table 1 Antimicrobial Peptides in Saliva

From: Oral Antimicrobial Peptides and Biological Control of Caries

Peptide Origin Role/comments Major Oral Microbial Targets References
Alpha-defensins HNP 1–4 Neutrophils, gingival sulcus, sites of inflammation, salivary duct cells Antibacterial, antifungal, antiviral. Present in GCF Candida albicans HIV S. mutans (poor) (Raj et al., 2000; Zhang et al., 2002) [43, 44]
LL-37 Neutrophils, gingival sulcus, salivary glands and ducts Primarily antibacterial S. mutans F. nucleatum A. actinomycetemcomitans Capnocytophaga sputigena (Ouhara et al., 2005; Tanaka et al., 2000) [17, 19]
Beta-defensins hBD1 hBD2 hBD3 Epithelia, salivary ducts Antibacterial, antifungal, antiviral. Part of the protective barrier function of epithelium. Secreted hBD1: Poor antibacterial hBD2, hBD3: S. mutans S. sanguis F. nucleatum P. gingivalis Candida albicans HIV (Joly et al., 2004; Maisetta et al., 2003; Quinones-Mateu et al., 2003)[15, 20, 18]
Histatins Salivary glands/ducts Antifungal Candida albicans (Oppenheim et al., 1988) [6]