Table 1 Estimated prevalence of Drug-Associated Gingival Enlargement according to the most frequently reported prevalence rates (Informational Paper: Drug-Associated Gingival Enlargement. J periodontal 2004;75:1424–1431)
Category | Pharmacologic Agent | Trade Name | Prevalence |
|---|---|---|---|
Anticonvulsants | Phenytoin | Dilantin | 50% |
| Â | Sodium valproate (valproic acid) | Depakene, Depacon, Epilim, Valpro | Rare |
| Â | Phenobarbitone | Phenobarbital, Donnatal | <5% |
| Â | Vigabatrin | Sabril | Rare |
| Â | Carbamazepine | Tegretol | None reported |
Immunosuppressants | Cyclosporin | Neoral, Sandimmune | Adults 25–30% Children >70% |
Calcium channel blockers | Nifedipine | Adalat, Nifecard, Procardia, Tenif | 6–15% |
| Â | Isradipine | DynaCirc | None reported |
| Â | Felodipine | Agon, Felodur, Lexxel, Plendil | Rare |
| Â | Amlodipine | Lotrel, Norvasc | Rare |
| Â | Verapamil | Calan, Covera, Isoptin, Tarka, Verelan | <5% |
|  | Diltiazem | Cardizem, Dilacor, Diltiamax, Tiazac | 5–20% |