Inclusion criteria | Exclusion criteria |
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Participants: People of any age or gender at risk of dental caries. | Reviews, case reports, abstracts, letters to editors, editorials, commentaries, in vitro and in situ studies utilising bovine or human enamel were excluded. |
Interventions: The use of Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) in accordance with the manufacturer’s instructions for the prevention or treatment of dental caries. | Non-english language studies were excluded. |
Comparisons: Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) (Test) versus a routine oral care regimen for the prevention of dental caries (Control) with or without comparisons to additional preventive products. | Studies utilising an artificial caries model or enamel demineralization model were excluded. |
Outcomes: Recognised clinical measures of early caries lesions or enamel demineralisation including - enamel microhardness, DIAGNOdent readings, QLF measurements, clinical caries scoring and visual inspection of photographic images. | Interventions: Only Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) formulations were considered. No other formulations of CPP-ACP such as gum, lozenges, solutions, mouthrinses, toothpastes or varnishes were considered. |
Study Design: Clinical trials | Studies in which Tooth Mousse® (MI Paste®) or Tooth Mousse Plus® (MI Paste Plus®) was not used in accordance with the manufacturer’s directions for use were excluded. |