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Table 3 Summary of the meta-analysis of the treatment effect between groups based on increments between baseline and end trial data presented by subgroup analysis based on periodontal diagnosis (see Additional file 1 for further details)

From: The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=

Index # online supportive

ID# Selected studies

‘Random/Fixed’ effect model

Periodontal diagnosis

Difference in means between groups (in mm)

95 % confidence interval

p-value

Test for heterogeneity*

Appendix

See Appendix S3

Test for overall effect

p-value

I2

Mean PD*

App. S52

II,III,VI,VIII,XVI,XVII

Random

Aggressive Periodontitis

−0.48

(−0.33; −0.63)

<0.00001

0.32

14 %

I,II,XIII

Chronic Periodontitis

−0.47

(−0.32; −0.63)

<0.00001

0.71

0 %

NA

Unknown

NA

NA

NA

NA

NA

Mean CAL**

App. S55

II,III,VI,VIII,XVI,XVII

Random

Aggressive Periodontitis

+0.39

(025; 0.53)

<0.00001

0.59

0 %

I, IX. XIII

Chronic Periodontitis

+0.32

(0.16; 0.47)

<0.00001

0.64

0 %

XX

Unknown

+0.00

(−0.35;0.35)

1.00

NA

NA

  1. * = test for subgroup analysis p = 0.96
  2. ** = test for subgroup analysis p = 0.12
  3. NA = not applicable