Managing patients taking novel oral anticoagulants (NOAs) in dentistry: a discussion paper on clinical implications

Table 1 Guide to discontinuation of dabigatran before elective surgery; indications are matched for renal function and risk of bleeding (van Ryn et al. 2010) [9]

Cretinine clearance (ml/min)	Time of discontinuation before surgery for standard risk of bleeding	Time of discontinuation before surgery for high risk of bleeding^a
>80	24 h	2–4 days
>50 to ≤ 80	24 h	2–4 days
>30 to ≤ 50	≥48 h	4 days
≤30^b	2–5 days	5 days

^aDeterminants of bleeding risk are: type of surgery (cardiac, neural, abdominal, surgery involving major organs or requiring complete haemostasis), advanced age, comorbidities (i.e. major cardiac, respiratory, liver diseases) and concomitant use of antiplatelet therapy
^bDabigatran controindicated

ISSN: 1472-6831