Skip to main content
Fig. 1 | BMC Oral Health

Fig. 1

From: Effect of recombinant PDGF-BB on bone formation in the presence of β-tricalcium phosphate and bovine bone mineral matrix: a pilot study in rat calvarial defects

Fig. 1

Histological images of treated and untreated rat calvarial defects at 45 days post-surgery: Representative images indicated partially healed defects, bridged by a conglomerate of biomaterial and new bone tissue for treated groups (TCP, TCP + PDGF, DBBM, DBBM + PDGF, Empty Control) (Levai-Laczko stain). New bone formation was mostly restricted to areas close to the original borders of defects in the control group. No substantial bone formation was observed in empty defects, only a thin layer of fibrous soft tissue separated the defect area from the underlying brain tissue. The empty control showed most of the defects occupied by connective tissue composed of large numbers of collagen fibers parallel to the wound defect. The defect sites that were originally treated with TCP and DBBM were partially bridged (arrow) by a conglomerate of biomaterial and new bone tissue. Immature osseous islands were also observed

Back to article page