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Table 3 Relative cytokine expression of gingival fibroblasts to sterile-filtered human saliva and salivary pellet preparations

From: Salivary pellets induce a pro-inflammatory response involving the TLR4–NF-kB pathway in gingival fibroblasts

Gene

Human saliva

SD

Human saliva + TAK-242

SD

4× washed pellet

SD

4× washed pellet + TAK-242

SD

CXCL8

2432.41*

2701.24

674.32

723.73

1438.89*

1406.80

450.75

366.06

IL6

159.02*

90.78

66.11

79.46

79.43*

50.59

36.81

27.74

ICAM1

59.90*

80.35

11.89

14.25

38.11*

46.33

8.73

8.18

  1. Gingival fibroblasts were stimulated with 10 fold diluted sterile-filtered human saliva and salivary pellet preparations that had been washed four times, with or without 25 μM of TLR4-receptor inhibitor TAK-242. Data represent the relative cytokine expression normalized to the untreated control. Three independent experiments with three different cell donors were performed
  2. * indicates p-values < 0.05
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BMC Oral Health

ISSN: 1472-6831

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