Author/publication year | Country | Sample size | Mean age | Inclusion criteria of diabetes, initial HbA1c (%), diabetes duration (Year) | Inclusion criteria of periodontal disease | Interventions | Duration of intervention | Outcome measures | Results |
---|---|---|---|---|---|---|---|---|---|
∆HbA1c(%)/FPG Level | |||||||||
Koromantzos et al., 2011 [36] | Greece | I = 30 C = 30 | I = 59.62 ± 7.95 C = 59.42 ± 9.8 | Type 2DM A1C levels (7 % −10 %) Initial HbA1c: I = 7.0–9.9 C = 7.0–10.2 Diabetes Duration I = 7.76 ± 4.33 C = 7.84 ± 6.80 | having at least 16 teeth present with at least eight sites (PPD) >6 mm and four sites with CAL >5 mm, distributed in at least two different quadrants. | I = SRP + OHI C = delayed treatment | 6 months | HbA1c | HbA1c Changes within the 1st 3 month I: 0.73 ± 0.66 C: 0.18 ± 0.59 HbAIc changes after 6th months I: 0.72 ± 0.93 C: 0.13 ± 0.46 |
Kumar et al., 2015 [30] | India | I = 15 C = 15 | NA | Type 2 DM HbA1c level 7.5–11 % Initial HbA1c: I = 8.13 ± 0.67 C = 8.09 ± 0.76 FPG (mg/dl) base line I = 153.63 ± 13.02 C = 157.35 ± 17.78 | 1, Chronic generalized periodontitis patients (Armitage Criteria) 2. Patients who have undergone periodontal treatment 6 months prior to the study | I = SRP and systemic Doxycycline C = no treatment | 3 months | HbA1c | HbA1c Changes after 3rd month I = 7.31 ± 0.50 C = 8.16 ± 0.74 Change in FPG after three months I = 145.47 ± 11.17 C = 157.93 ± 17.44 |
Kanduluru and Naganandini, 2014 [32] | India | I = 35 C = 35 | I = 47.14 ± 5.28 C = 48.86 ± 3.81 | Type 2DM HbA1c level Initial HbA1c: I = 8.49 ± 1.50 C = 8.04 ± 0.70 Initial FPG Level I = 131.31 ± 21.48 C = 127.34 ± 19.89 Diabetes duration I = 1–15 years C = 1–15 years | 1. pocket depth [PD] 4–6 mm involving >30 % sites) 2. generalized moderate periodontitis | I = SRP + OHI C = OHI | 3 months | HbAIc FBS | HbA1c Changes after 3rd month I = 8.47 ± 0.89 C = 8.27 ± 0.63 FPG changes after 3rd months I = 122.64 ± 17.81 C = 136.57 ± 15.07 |
Engebretson et al., 2013 [34] | USA | I = 257C = 257 | I = 56.7 ± 10.5 C = 57.9 ± 9.6 | Type 2Dm HbA1c level 7.0 % −9.0 % Initial HbA1c: I = 7.84 (0.65) C = 7.78 (0.60) Baseline FPG I = 150 (125–174) C = 147 (122–172) Diabetes duration I = 12.3 (8.2) C = 11.3 (8.4) | 1. a minimum of 16 natural teeth 2. CAL/PD >5 mm in 2 or more quadrants of the mouth 3. No periodontal treatment in the prior 6 months. | I = SRP + OHI chlorhexidine gluconate, toothbrush, toothpaste, Dental floss. C = OHI | 6 month | HbA1c FBS | Mean Change of HbA1c (95 % CI) at 3rd month I = 0.14(0.02–0.27) C = 0.11(−0.02 to 0.24) Mean Change of HbA1c (95 % CI) at the end of 6th month I = 0.15(−0.01 to 0.30) C = 0.09(−0.06 to 0.25) |
Gay et al., 2014 [35] | USA | I = 66 C = 60 | I = 51.5( 9.0) C = 54.0(10.2) | 1. Type 2DM HbA1c level 4.0–15.0 % Initial HbA1c: I = 9.0 ± 2.3 C = 8.4 ± 2.0 2. nonsmokers | 1. no systemic antibiotic therapy within 6 months of recruitment, 2. the presence of localized or generalized severe chronic periodontitis | I = SRP + OHI C = OHI | 4 months | HbA1c | HbA1c Changes after 4th month I = 8.4 ± 1.9 C = 8.1 ± 1.8 |
Kaur et al., 2015 [31] | India | I = 50 C = 50 | I = 51.82 ± 5.85C = 52.94 ± 6.03 | 1. Type 2DM Initial HbA1c: I = 8.17 ± 2.49 C = 7.87 ± 2.56 2. Duration of DM I = 8.57 ± 6.39 C = 7.05 ± 4.43 FPG (mmol/L) I = 137.12 ± 59.71 C = 120.74 ± 41.47 | 1. presence of ≥12 teeth 2. ≥2 interproximal sites, not on the same tooth, with an attachment loss ≥4 mm, or PD ≥5 mm. 3. ≥2 interproximal sites, not on the same tooth, with an attachment loss ≥6 mm, and one or probing depth ≥5 mm | I = OHI + SRP C = no treatment | 3,6 months | HbA1c | HbA1c Changes in the end of 3rd month. I = 7.49 ± 1.83 C = 7.96 ± 2.65 HbA1c Changes in the end of 6th month. I = 7.29 ± 1.61 C = 8.06 ± 2.72 Change in FPG after three months I = 135.88 ± 59.54 C = 121.71 ± 42.39 Change in FPG after six months. I = 132.10 ± 56.91, C = 122.75 ± 42.67 |
Telgi et al., 2013 [33] | India | I = 20 C = 20 | NA | 1. Type 2 DM Initial HbA1c: I = 7.68 ± 0.63 C = 7.74 ± 0.59 2. blood sugar controlled only with oral hypoglycemic agents FPG(mg/dl) I = 210.50 ± 4.98 C = 210.5 ± 41.98 | 1. the presence of aminimum of 28 teeth 2. pocket depth of 4–5 mm) 3. no systemic antibiotic administration and no periodontal treatment in last six months | A = Scaling+ mouthwash+ brushing C = brushing | 3 month | HbA1c | HbA1c after 3 month I = 7.10 ± 0.64 C = 7.75 ± 0.48 FPG after three month I = 181.70 ± 41.28 C = 210.1 ± 43.02 |