Effect of the plant-based hemostatic agent Ankaferd Blood Stopper® on the biocompatibility of mineral trioxide aggregate

Table 1 Comparison of results belonging to the study groups at study intervals for the 5 events assessed

Histologic events	Experimental periods	Study groups			p
Histologic events	Experimental periods	MTA	MTA-ABS	Control	p
Inflammatory response (Mean ± SD)	7 days	1 ± 0	1 ± 0	0,75 ± 0,46	0,075
	30 days	0 ± 0	0 ± 0	0 ± 0	1,000
	60 days	0 ± 0	0 ± 0	0 ± 0	1,000
	90 days	0 ± 0	0 ± 0	0 ± 0	1,000
	p	0,001 ^*	0,001 ^*	0,001 ^*
Foreign body reaction (Mean ± SD)	7 days	0,2 ± 0,42	0,3 ± 0,48	0 ± 0	0,262
	30 days	0,1 ± 0,32	0,2 ± 0,42	0 ± 0	0,407
	60 days	0 ± 0	0,1 ± 0,32	0 ± 0	0,407
	90 days	0 ± 0	0 ± 0	0 ± 0	1,000
	p	0,276	0,281	1,000
Fibrosis (Mean ± SD)	7 days	1 ± 0	1,4 ± 0,52	1,25 ± 0,46	0,097
	30 days	0,7 ± 0,48	0,4 ± 0,52	0,38 ± 0,52	0,300
	60 days	0,1 ± 0,32	0,1 ± 0,32	0,25 ± 0,46	0,603
	90 days	0,2 ± 0,42	0,5 ± 0,53	0,75 ± 0,46	0,071
	p	0,001 ^*	0,001 ^*	0,004 ^*
New bone formation (Mean ± SD)	7 days	1,7 ± 0,48	1,6 ± 0,52	1,13 ± 0,35	0,044 ^***
	30 days	2,3 ± 0,48	2,2 ± 0,42	2,38 ± 0,74	0,681
	60 days	2,7 ± 0,48	2,6 ± 0,52	2,25 ± 0,46	0,154
	90 days	3 ± 0	3 ± 0	3 ± 0	1,000
	p	0,001 ^*	0,001 ^*	0,001 ^*
Necrosis [n(%)]	7 days	0(%0)	4(%40)	0(%0)	0,024 ^***
	30 days	0(%0)	0(%0)	0(%0)	-
	60 days	0(%0)	0(%0)	0(%0)	-
	90 days	0(%0)	0(%0)	0(%0)	-
	p	-	0,009 ^**	-

MTA Mineral trioxide aggregate, ABS Ankaferd blood stopper, SD Standart deviation; ^*Significant difference within the groups at p < 0.05; ^**Significant difference within the groups at p < 0.01; ^***Significant difference among the groups at p < 0.05; Bold data confines only to p values both within or among the groups

ISSN: 1472-6831