Fig. 3

Angiogenin / ANGIOGENIN production in spheroid cultures of dental pulp-derived cells in response to L-mimosine and hypoxia. Dental pulp-derived cells (DPC) in spheroid cultures were treated with L-mimosine (L-MIM) at 1 mM or hypoxia for 24 h. mRNA levels of angiogenin (a) and protein levels of ANGIOGENIN (b) were assessed by RT-qPCR and ELISA, respectively. a Bars represent mRNA levels as mean + standard deviation, relative to the normoxic control (dashed line). Experiments were conducted twice with 3 different donors, respectively. Kruskal Wallis test p > 0.05. b Bars represent mean + standard deviation of ANGIOGENIN protein levels relative to the normoxic control (dashed line). Experiments were conducted twice with three different donors, respectively. Kruskal Wallis test p < 0.05. post hoc Mann-Whitney * p < 0.05 vs. control (dashed line)