Table 1 Search strategy

((((“Periodontal Diseases”[Mesh] OR “Periodontitis”[Mesh]) OR “Dental Scaling”[Mesh]) OR “Periodontics”[Mesh]) OR (((((((periodontal disease[Title/Abstract] OR periodontitis[Title/Abstract]) OR periodontal pocket[Title/Abstract]) OR periodontal tissue[Title/Abstract]) OR periodontal therapy[Title/Abstract]) OR periodontal treatment[Title/Abstract]) OR scaling and root planning[Title/Abstract]) OR SRP[Title/Abstract]) AND ((((leptin[Title/Abstract] OR adiponectin[Title/Abstract]) OR adipokine[Title/Abstract]) OR adipocytokine[Title/Abstract]) OR ((“Adipokines”[Mesh] OR “Leptin”[Mesh]) OR “Adiponectin”[Mesh]))

‘periodontal disease’/exp OR ‘periodontitis’/exp OR ‘periodontics’/exp OR ‘periodontal disease’:ab,ti OR ‘periodontitis’:ab,ti OR ‘periodontal pocket’:ab,ti OR ‘periodontal tissue’:ab,ti OR ‘periodontal therapy’:ab,ti OR ‘periodontal treatment’:ab,ti OR ‘scaling and root planning’:ab,ti OR ‘srp’:ab,ti AND (‘leptin’/exp OR ‘adiponectin’/exp OR ‘adipocytokine’/exp OR ‘leptin’:ab,ti OR ‘adiponectin’:ab,ti OR ‘adipokine’:ab,ti OR ‘adipocytokine’:ab,ti)

#1:TS = (periodontal disease) OR TS = (periodontitis) OR TS = (periodontal treatment) OR TS = (periodontal therapy) OR TS = (SRP) OR TS = (scaling and root planning) OR TS = (periodontal pocket) OR TS = (periodontal tissue)

#2:TS = (adipokine) OR TS = (adipocytokine) OR TS = (leptin)OR TS = (adiponectin)

#1 AND #2

#1: “periodontal disease”:ti,ab,kw; #2:“periodontitis”:ti,ab,kw; #3: periodontal treatment:ti,ab,kw; #4: periodontal therapy:ti,ab,kw; #5: scaling and root planning:ti,ab,kw; #6: SRP:ti,ab,kw; #7: “periodontal pocket”:ti,ab,kw; #8: periodontal tissue:ti,ab,kw;

#9: #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8;

#10:“adipokine”:ti,ab,kw; #11: “adipocytokine”:ti,ab,kw; #12: “leptin”:ti,ab,kw; #13:“adiponectin”:ti,ab,kw;

#14: #10 or #11 or #12 or #13;

#15 :#9 and #14