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Table 3 The overall and subgroup analyses

From: Association of circulating leptin and adiponectin with periodontitis: a systematic review and meta-analysis

Overall and subgroup analyses

No. of observations

Association

Heterogeneity

Model

Publication bias (P)

SMD (95% CI)

p value

I 2 (%)

P value

L1

20

0.799 (0.308–1.289)

0.000

92.2

0.000

Random

0.289

BMI <30

14

0.987 (0.317–1.657)

0.000

93.9

0.000

Random

 

BMI ≥30

3

0.024 (−0.790–0.839)

0.953

81.3

0.005

Random

 

CP

13

0.708 (0.142–1.273)

0.014

91.6

0.000

Random

 

AP

5

1.046 (−0.366–2.458)

0.147

94.8

0.000

Random

 

Systemic disease (free)

15

0.822 (0.225–1.418)

0.007

92.1

0.000

Random

 

Systemic disease (mixed)

5

0.721 (−0.135–1.576)

0.099

91.6

0.000

Random

 

Smoking (free)

9

0.656 (−0.076–1.389)

0.079

90.6

0.000

Random

 

Smoking (mixed)

11

0.913 (0.223–1.602)

0.009

93.6

0.000

Random

 

A1

14

−0.323 (−0.525 to −0.121)

0.002

50.2

0.016

Random

0.203

BMI <30

10

−0.243(−0.390 to −0.096)

0.001

48.8

0.040

Fixed

 

BMI ≥30

3

−0.326 (−0.677–0.024)

0.068

33.9

0.220

Fixed

 

CP

12

−0.317 (−0.540 to −0.095)

0.005

56.3

0.009

Random

 

AP

1

NA

 

Systemic disease (free)

9

−0.457 (−0.809 to −0.104)

0.011

60.2

0.010

Random

 

Systemic disease (mixed)

5

−0.206 (−0.374 to −0.038)

0.016

0.0

0.427

Fixed

 

Smoking (free)

7

−0.480 (−0.923 to −0.037)

0.034

69.2

0.003

Random

 

Smoking (mixed)

7

−0.227 (−0.387 to −0.068)

0.005

0.0

0.530

Fixed

 

L2

9

−0.412 (−0.864–0.040)

0.074

79.7

0.000

Random

0.065

BMI <30

6

−0.541 (−1.213–0.130)

0.114

86.4

0.000

Random

 

BMI ≥30

3

−0.201 (−0.562–0.159)

0.273

0.0

0.393

Fixed

 

Smoking (free)

7

−0.439 (−1.052–0.174)

0.160

84.4

0.000

Random

 

Smoking (Mixed)

2

−0.336 (−0.707–0.034)

0.075

0.0

0.326

Fixed

 

A2

9

0.298 (0.117–0.479)

0.001

33.2

0.157

Fixed

0.042

BMI <30

5

0.384 (0.161–0.607)

0.001

54.2

0.068

Fixed

 

BMI ≥30

3

0.171 (−0.212–0.554)

0.382

0.0

0.479

Fixed

 

SRP

6

0.117 (−0.150–0.384)

0.389

0.0

0.634

Fixed

 

SRP + peridontal surgery

2

0.409 (−0.193–1.011)

0.183

74.6

0.047

Random

 

SRP + topical antibiotics

1

NA

 

Systemic disease (free)

7

0.106 (−0.132–0.344)

0.382

0.0

0.749

Fixed

 

Systemic disease (T2DM)

2

0.466 (−0.066–0.997)

0.086

60.9

0.110

Random

 
  1. AP Aggressive periodontitis, BMI body mass index, CP chronic periodontitis, NA not available, T2DM type 2 diabetes mellitus, SRP scaling and root planning, L1 serum levels of leptin in patients with periodontitis versus healthy individuals, A1 serum levels of adiponectin in patients with periodontitis versus healthy individuals, L2 serum levels of leptin in patients with periodontitis before versus after periodontal treatment, A2 serum levels of adiponectin in patients with periodontitis before versus after periodontal treatment