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Table 4 GRADE assessment for quality of evidence

From: The effectiveness of vibrational stimulus to accelerate orthodontic tooth movement: a systematic review

Patient or population: patients with orthodontic treatment Settings: RCT and CCT Intervention: vibrational stimulus
Outcomes Illustrative comparative risks (95% CI) Relative effect(95% CI) No of Participants(studies) Quality of the evidence(GRADE) Comments
Assumed risk Corresponding risk
  Control Vibrational stimulus     
rate of OTM in alignment See comment See comment Not estimable 187(3 studies) very lowa,b,c vibrational stimulus did not increase tooth movement in alignment
rate of OTM in canine retraction See comment See comment Not estimable 60(2 studies) very lowb,d,e vibrational stimulus increased the rate of canine retraction
  1. aUnclear risk in random sequence generation, allocation concealment, blinding of participants, incomplete reporting and other bias
  2. bThe procedure of orthodontic treatment and vibrational stimulus and follow-up durations varied
  3. cOnly three studies with limited sample size (n = 187) were included
  4. dHigh risk of bias in randomization, blinding and other bias
  5. eOnly two studies with limited sample size (n = 60) were included