Serum and salivary ferritin and Hepcidin levels in patients with chronic periodontitis and type 2 diabetes mellitus

Table 2 Levels of ferritin, hepcidin and hepcidin/ferritin in serum and saliva

	Control	CP	T2DM	CP + T2DM	P-value
Serum ferritin (ng/ml, Median (IQR))	196.2 (106.6, 241.6)	265.1 (166.1, 358.5)	196.3 (88.8, 369.6)	197.7 (128.9, 366.6)	P₁ = 0.008^a* P₂ = 0.015^a* P₃ = 0.036^a*
log serum ferritin (Mean ± SD)	2.20 ± 0.32	2.42 ± 0.20	2.23 ± 0.40	2.38 ± 0.31	P₁ = 0.008^a* P₂ = 0.015^a* P₃ = 0.036^a*
Serum hepcidin (ng/ml, Mean ± SD)	179.37 ± 79.86	249.56 ± 77.15	197.92 ± 103.04	218.36 ± 94.05	P₁ = 0.003^a* P₂ = 0.036^a* P₃ = 0.040^a*
Serum hepcidin/ferritin (Mean ± SD)	1.00 ± 0.18	0.95 ± 0.26	1.00 ± 0.31	0.88 ± 0.24	P₂ = 0.007^a* P₄ = 0.015^a*
Salivary ferritin (ng/ml, Median (IQR))	6.50 (5.49, 9.56)	16.74 (8.44, 23.93)	12.61 (7.47, 26.16)	12.81 (7.42, 18.13)	P₁ = 0.008^a* P₅ = 0.014^a*
log salivary ferritin (Mean ± SD)	0.83 ± 0.32	1.14 ± 0.36	1.11 ± 0.46	1.06 ± 0.30	P₁ = 0.008^a* P₅ = 0.014^a*
Salivary hepcidin (ng/ml, Median (IQR))	1.12 (0.89, 1.73)	1.64 (0.93, 3.19)	1.79 (0.93, 5.14)	1.54 (0.99, 3.80)	P = 0.307^a
1/(salivary hepcidin) (Mean ± SD)	0.84 ± 0.38	0.66 ± 0.44	0.62 ± 0.44	0.63 ± 0.36	P = 0.307^a
Salivary hepcidin/ferritin (Median (IQR))	0.17 (0.12, 0.37)	0.11 (0.08, 0.34)	0.18 (0.90, 0.39)	0.13 (0.92, 0.34)	P = 0.939^a
log (salivary hepcidin/ferritin) (Mean ± SD)	−0.69 ± 0.34	− 0.77 ± 0.51	−0.72 ± 0.42	− 0.77 ± 0.38	P = 0.939^a

P₁: Control vs CP; P_2: Control vs T2DM + CP; P₃: CP vs T2DM; P₄: T2DM vs T2DM + CP; P_5: Control vs T2DM
^aAnalysis of covariance (ANCOVA)
^*Significantly different P < 0.05

ISSN: 1472-6831