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Table 3 Dental caries vaccine trials using human subjects

From: Are the mutans streptococci still considered relevant to understanding the microbial etiology of dental caries?

Study Immunization Route Outcome Measure
Krasse et al.; 1978 Topical S. mutans specific IgA
Mestecky et al.; 1978 Oral S. mutans specific IgA
Gahnberg et al.; 1983 Oral S. mutans specific IgA; Recovery of S. mutans
Cole et al.; 1984 Oral Antibody response; Recovery of S. mutans
Gregory et al.; 1987 Oral S. mutans specific IgA; Recovery of S. mutans
Czerkinsky et al.; 1987 Oral S. mutans specific IgA or IgM
Smith et al.; 1987 Oral S. mutans specific IgA; S. mutans to total strep ratios
Ma et al.; 1987 Passive Recovery of S. mutans
Smith and Taubman; 1990 Topical Antibody against GTF; S. mutans to total strep ratios Recolonization with S. mutans
Ma et al.; 1990 Passive S. mutans colonization
Childers et al.; 1990 Oral Specific salivary IgA; Plasma IgG response
Filler et al.; 1991 Passive Recovery of S. mutans
Childers et al.; 1997 Nasal Specific salivary, nasal and serum IgA, IgM, and IgG
Hatta et al.; 1997 Passive S. mutans to total strep ratios
Ma et al.; 1998 Passive Protection against colonization
Childers et al.; 1999 Nasal Specific salivary, nasal and serum IgA and IgG
Shimazaki et al.; 2001 Passive Recolonization of S. mutans
Childers et al.; 2002 Nasal Specific salivary, nasal and serum IgA and IgG