Table 1 Meta-analysis of TP53 rs1042522 and OSCC risk
Genetic models | Overall/Subgroup | N | Case/control | ORs (95% CIs) | P A | I2 (%) | P H | Statistical model | |
|---|---|---|---|---|---|---|---|---|---|
allele C vs. G | overall | Â | 17 | 3047/3305 | 1.02 (0.90, 1.15) | 0.741 | 55.0 | 0.003 | Random |
Control source | PB | 13 | 2477/2485 | 1.01 (0.86, 1.18) | 0.925 | 63.7 | 0.001 | ||
HB | 3 | 381/704 | 1.01 (0.83, 1.22) | 0.933 | 0.0 | 0.663 | |||
Location | India | 4 | 577/498 | 1.29 (0.79, 2.08) | 0.306 | 79.1 | 0.002 | ||
USA | 4 | 942/1357 | 0.96 (0.84, 1.10) | 0.560 | 0.0 | 0.768 | |||
China | 3 | 1115/767 | 1.02 (0.79, 1.31) | 0.886 | 68.5 | 0.042 | |||
Ethnicity | Asian | 12 | 2028/1807 | 1.10 (0.93, 1.29) | 0.253 | 58.4 | 0.006 | ||
Caucasian | 4 | 817/1165 | 0.86 (0.70, 1.06) | 0.158 | 46.0 | 0.135 | |||
Disease type | oral cavity | 6 | 1295/1372 | 1.12 (0.92, 1.36) | 0.244 | 59.5 | 0.030 | ||
HPV16(−) | 4 | 208/255 | 1.06 (0.47, 2.40) | 0.884 | 83.4 | < 0.001 | |||
HPV16(+) | 4 | 93/197 | 1.38 (0.88, 2.16) | 0.157 | 0.0 | 0.865 | |||
carrier C vs. G | overall | Â | 17 | 3047/3305 | 0.99 (0.91, 1.08) | 0.853 | 0.0 | 0.460 | Fixed |
Control source | PB | 13 | 2477/2485 | 0.98 (0.89, 1.08) | 0.685 | 20.0 | 0.242 | ||
HB | 3 | 381/704 | 1.00 (0.80, 1.25) | 0.990 | 0.0 | 0.878 | |||
Location | India | 4 | 577/498 | 1.02 (0.84, 1.25) | 0.820 | 40.6 | 0.168 | ||
USA | 4 | 942/1357 | 0.97 (0.83, 1.12) | 0.666 | 0.0 | 0.902 | |||
China | 3 | 1115/767 | 1.01 (0.87, 1.18) | 0.869 | 8.9 | 0.334 | |||
Ethnicity | Asian | 12 | 2028/1807 | 1.03 (0.92, 1.15) | 0.601 | 0.0 | 0.600 | ||
Caucasian | 4 | 817/1165 | 0.89 (0.76, 1.05) | 0.179 | 35.6 | 0.199 | |||
Disease type | oral cavity | 6 | 1295/1372 | 1.06 (0.93, 1.20) | 0.414 | 0.0 | 0.510 | ||
HPV16(−) | 4 | 208/255 | 0.94 (0.66, 1.34) | 0.729 | 69.4 | 0.020 | |||
HPV16(+) | 4 | 93/197 | 1.20 (0.71, 2.01) | 0.493 | 0.0 | 0.926 | |||
homozygote CC vs. GG | overall | Â | 17 | 3047/3305 | 1.03 (0.88, 1.21) | 0.085 | 33.9 | 0.733 | Fixed |
Control source | PB | 13 | 2477/2485 | 1.00 (0.83, 1.20) | 0.989 | 45.0 | 0.040 | ||
HB | 3 | 381/704 | 1.06 (0.69, 1.62) | 0.799 | 0.0 | 0.587 | |||
Location | India | 4 | 577/498 | 1.04 (0.74, 1.47) | 0.812 | 75.6 | 0.006 | ||
USA | 4 | 942/1357 | 0.97 (0.70, 1.34) | 0.846 | 0.0 | 0.945 | |||
China | 3 | 1115/767 | 1.00 (0.76, 1.32) | 0.997 | 65.3 | 0.056 | |||
Ethnicity | Asian | 12 | 2028/1807 | 1.06 (0.88, 1.28) | 0.559 | 53.1 | 0.015 | ||
Caucasian | 4 | 817/1165 | 0.91 (0.63, 1.31) | 0.602 | 0.0 | 0.972 | |||
Disease type | oral cavity | 6 | 1295/1372 | 1.16 (0.92, 1.46) | 0.224 | 56.1 | 0.044 | ||
HPV16(−) | 4 | 208/255 | 1.46 (0.79, 2.73) | 0.230 | 51.4 | 0.103 | |||
HPV16(+) | 4 | 93/197 | 2.40 (0.96, 5.99) | 0.061 | 0.0 | 0.843 | |||
heterozygote GC vs. GG | overall | Â | 17 | 3047/3305 | 0.99 (0.89, 1.11) | 0.882 | 37.4 | 0.061 | Fixed |
Control source | PB | 13 | 2477/2485 | 0.98 (0.86, 1.11) | 0.706 | 50.1 | 0.020 | ||
HB | 3 | 381/704 | 0.98 (0.75, 1.28) | 0.861 | 0.0 | 0.969 | |||
Location | India | 4 | 577/498 | 1.10 (0.82, 1.48) | 0.541 | 0.0 | 0.402 | ||
USA | 4 | 942/1357 | 0.94 (0.79, 1.12) | 0.470 | 0.0 | 0.709 | |||
China | 3 | 1115/767 | 1.10 (0.89, 1.35) | 0.386 | 61.0 | 0.076 | |||
Ethnicity | Asian | 12 | 2028/1807 | 1.10 (0.95, 1.28) | 0.196 | 0.0 | 0.595 | ||
Caucasian | 4 | 817/1165 | 0.81 (0.67, 0.98) | 0.030 | 71.5 | 0.014 | |||
Disease type | oral cavity | 6 | 1295/1372 | 1.15 (0.96, 1.38) | 0.125 | 0.0 | 0.715 | ||
HPV16(−) | 4 | 208/255 | 0.93 (0.30, 2.92) | 0.904 | 80.6 | 0.001 | |||
HPV16(+) | 4 | 93/197 | 0.96 (0.32, 2.86) | 0.937 | 40.9 | 0.166 | |||
dominant GC + CC vs. GG | overall |  | 17 | 3047/3305 | 1.01 (0.86, 1.19) | 0.969 | 47.6 | 0.015 | Random |
Control source | PB | 13 | 2477/2485 | 1.00 (0.81, 1.23) | 0.936 | 57.5 | 0.005 | ||
HB | 3 | 381/704 | 1.01 (0.86, 1.19) | 0.181 | 0.0 | 0.877 | |||
Location | India | 4 | 577/498 | 1.31 (0.77, 2.21) | 0.321 | 57.8 | 0.068 | ||
USA | 4 | 942/1357 | 0.94 (0.80, 1.11) | 0.481 | 0.0 | 0.700 | |||
China | 3 | 1115/767 | 1.07 (0.72, 1.58) | 0.736 | 70.5 | 0.034 | |||
Ethnicity | Asian | 12 | 2028/1807 | 1.13 (0.93, 1.36) | 0.220 | 32.9 | 0.127 | ||
Caucasian | 4 | 817/1165 | 0.78 (0.56, 1.07) | 0.123 | 64.2 | 0.039 | |||
Disease type | oral cavity | 6 | 1295/1372 | 1.15 (0.95, 1.40) | 0.144 | 16.2 | 0.309 | ||
HPV16(−) | 4 | 208/255 | 1.04 (0.32, 3.37) | 0.942 | 83.9 | < 0.001 | |||
HPV16(+) | 4 | 93/197 | 1.21 (0.62, 2.37) | 0.573 | 0.0 | 0.513 | |||
recessive CC vs. GG + GC | overall |  | 17 | 3047/3305 | 1.00 (0.87, 1.16) | 0.980 | 22.8 | 0.189 | Fixed |
Control source | PB | 13 | 2477/2485 | 0.98 (0.84, 1.15) | 0.794 | 36.4 | 0.092 | ||
HB | 3 | 381/704 | 1.06 (0.71, 1.59) | 0.765 | 0.0 | 0.560 | |||
Location | India | 4 | 577/498 | 1.00 (0.75, 1.33) | 0.997 | 75.6 | 0.006 | ||
USA | 4 | 942/1357 | 0.99 (0.72, 1.36) | 0.954 | 0.0 | 0.978 | |||
China | 3 | 1115/767 | 0.95 (0.74, 1.21) | 0.652 | 13.5 | 0.315 | |||
Ethnicity | Asian | 12 | 2028/1807 | 1.00 (0.85, 1.18) | 0.977 | 46.3 | 0.039 | ||
Caucasian | 4 | 817/1165 | 0.98 (0.69, 1.40) | 0.927 | 0.0 | 0.977 | |||
Disease type | oral cavity | 6 | 1295/1372 | 1.00 (0.85, 1.18) | 0.392 | 57.6 | 0.038 | ||
HPV16(−) | 4 | 208/255 | 1.00 (0.85, 1.18) | 0.353 | 16.3 | 0.310 | |||
HPV16(+) | 4 | 93/197 | 1.00 (0.85, 1.18) | 0.031 | 0.0 | 0.445 | |||