Effect of TP53 rs1042522 on the susceptibility of patients to oral squamous cell carcinoma and oral leukoplakia: a meta-analysis

Table 2 Meta-analysis of TP53 rs1042522 and OL risk

Genetic models	Overall/Subgroup		N	Case/control	ORs (95% CIs)	P _A	I² (%)	P _H	Statistical model
allele C vs. G	Overall		6	391/763	1.16 (0.73, 1.84)	0.525	77.1	0.001	Random
	Control source	PB	4	291/647	0.77 (0.59, 1.01)	0.055	21.7	0.280
	Location	India	4	307/465	1.05 (0.57, 1.92)	0.879	78.7	0.003
	Ethnicity	Asian	5	377/745	0.99 (0.65, 1.49)	0.952	71.8	0.007
carrier C vs. G	overall		6	391/763	0.93 (0.76, 1.15)	0.510	41.0	0.132	Fixed
	Control source	PB	4	291/647	0.82 (0.65, 1.03)	0.090	0.0	0.713
	Location	India	4	307/465	0.89 (0.70, 1.13)	0.353	39.1	0.177
	Ethnicity	Asian	5	377/745	0.90 (0.73, 1.11)	0.334	19.3	0.292
homozygote CC vs. GG	overall		6	391/763	1.14 (0.49, 2.62)	0.764	69.2	0.006	Random
	Control source	PB	4	291/647	0.52 (0.34, 0.80)	0.003	1.0	0.387
	Location	India	4	307/465	1.06 (0.33, 3.37)	0.920	75.6	0.006
	Ethnicity	Asian	5	377/745	0.93 (0.41, 2.08)	0.854	67.5	0.015
heterozygote GC vs. GG	overall		6	391/763	0.95 (0.71, 1.29)	0.760	45.2	0.104	Fixed
	Control source	PB	4	291/647	0.85 (0.61, 1.18)	0.330	0.0	0.700
	Location	India	4	307/465	0.81 (0.57, 1.15)	0.239	0.0	0.827
	Ethnicity	Asian	5	377/745	0.87 (0.64, 1.19)	0.388	0.0	0.803
dominant GC + CC vs. GG	overall		6	391/763	1.20 (0.66, 2.18)	0.557	63.1	0.019	Random
	Control source	PB	4	291/647	0.73 (0.53, 1.00)	0.050	0.0	0.460
	Location	India	4	307/465	0.88 (0.51, 1.50)	0.629	32.0	0.220
	Ethnicity	Asian	5	377/745	0.87 (0.60, 1.25)	0.446	21.0	0.281
recessive CC vs. GG + GC	overall		6	391/763	1.04 (0.53, 2.05)	0.907	68.9	0.007	Random
	Control source	PB	4	291/647	0.59 (0.41, 0.85)	0.004	0.0	0.505
	Location	India	4	307/465	1.11 (0.42, 2.98)	0.829	79.7	0.002
	Ethnicity	Asian	5	377/745	0.97 (0.47, 2.01)	0.943	73.6	0.004

OL, oral leukoplakia; N, number of case-control studies; PB: population-based control; ORs, odd ratios; CIs, confidence intervals; P_A, P value of association test; P_H, P values of heterogeneity test
P_A value <0.05, the number is in bold

ISSN: 1472-6831