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Fig. 2 | BMC Oral Health

Fig. 2

From: Chronodentistry: the role & potential of molecular clocks in oral medicine

Fig. 2

The transcriptional-translational feedback loop of the circadian clock. Circadian locomotor output cycles kaput (CLOCK) and aryl hydrocarbon receptor nuclear translocator-like (BMAL1) dimerize in the cell nucleus (CLOCK:BMAL1) to act as transcription factors when binding to E-box elements in the promoter regions of cryptochrome (CRY) and period (PER). Produced CRY and PER mRNA is translated in the cytoplasm to CRY and PER proteins. CRY and PER accumulate and form a dimer (CRY:PER) that inhibits CLOCK:BMAL1 activity. Adapted from [92]

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