A randomized, double-blind, placebo-controlled multicenter study for evaluating the effects of fixed-dose combinations of vitamin C, vitamin E, lysozyme, and carbazochrome on gingival inflammation in chronic periodontitis patients

Table 3 Generalized estimating equations for decreasing status of various endpoints

	β-estimate	SE	Odds ratio	p-value
GI (N = 97)
Intercept	0.505	0.744	–	0.497
Group (reference; control)	0.899	0.394	2.457	0.022^†
Visits (reference; week 4)	− 0.047	0.206	0.954	0.819
Gender (reference; male)	−0.246	0.383	0.782	0.521
Age	−0.010	0.015	0.990	0.479
PI (N = 97)
Intercept	−0.092	0.540	–	0.864
Group (reference; control)	0.337	0.300	1.401	0.261
Visits (reference; week 4)	0.308	0.294	1.360	0.296
Gender (reference; male)	0.085	0.312	1.089	0.784
Age	−0.002	0.011	0.998	0.867
PD (N = 97)
Intercept	0.277	0.599	–	0.644
Group (reference; control)	0.387	0.340	1.473	0.255
Visits (reference; week 4)	0.134	0.257	1.144	0.601
Gender (reference; male)	−0.372	0.346	0.689	0.283
Age	0.000	0.012	1.000	0.983
CAL (N = 97)
Intercept	0.835	0.674	–	0.215
Group (reference; control)	0.169	0.359	1.184	0.638
Visits (reference; week 4)	−0.309	0.228	0.734	0.175
Gender (reference; male)	−0.386	0.364	0.680	0.289
Age	−0.008	0.013	0.992	0.524
100 mm VAS (N = 97)
Intercept	−0.971	0.779	–	0.213
Group (reference; control)	0.364	0.408	1.440	0.372
Visits (reference; week 4)	0.488	0.202	1.629	0.016^†
Gender (reference; male)	0.475	0.423	1.609	0.261
Age	0.021	0.016	1.021	0.192

GI gingival index, PI plaque index, PD probing depth, CAL clinical attachment level, VAS visual analog scale
^†Statistically significant difference using GEE method (p < 0.05)

ISSN: 1472-6831