Investigation of molecular biomarker candidates for diagnosis and prognosis of chronic periodontitis by bioinformatics analysis of pooled microarray gene expression datasets in Gene Expression Omnibus (GEO)

Table 1 Summary of individual studies of chronic periodontitis

GEO gene set ID	GSE10334	GSE16134	GSE23586
Platform	GPL570: Affymetric Human Geneme U133 plus 2.0 Array
Number of Healthy Control Persons vs. Chronic Periodontitis Persons	64 vs. 63	69 vs. 65	3 vs. 3
Clinical Data
Healthy Control	PD ≤ 4 mm, AL ≤ 2 mm, BoP-	PD ≤ 4 mm, AL ≤ 2 mm, BoP-	PD ≤ 2 mm, AL = 0, BoP-, GI = 0
Chronic Periodontitis	PD > 4 mm, AL ≥ 3 mm, BoP+	PD > 4 mm, AL ≥ 3 mm, BoP+	PD ≥ 5 mm, AL ≥ 5 mm, BoP+, GI ≥ 1
Diabetes	Not	Not	Not
Pregnant	Not	Not	Not
Smoking	Not	Not	Not
	No systemic antibiotics or anti-inflammatory drugs for ≥6 months	No systemic antibiotics or anti-inflammatory drugs for ≥6 months	No systemic antibiotics or anti-inflammatory drugs for ≥6 months
PubMed ID	18,980,520	19,835,625	21,382,035
PubMed ID	18,980,520	24,646,639	21,382,035

PD Probing Depth, AL Attachment Level, BoP Bleeding on Probing, GI Gingival Index

ISSN: 1472-6831