Table 5 Functional and pathway enrichment analyses of downregulated genes in chronic periodontitis
Category | Term | Genes | p-value | FDR (%) |
|---|---|---|---|---|
GOTERM_BP_FAT | GO:0008544~epidermis development | LOR, FLG, FOXN1, AHNAK2, KRT10, CALML5 | 4.02E-05 | 0.05644221 |
GOTERM_BP_FAT | GO:0007398~ectoderm development | LOR, FLG, FOXN1, AHNAK2, KRT10, CALML5 | 5.84E-05 | 0.082008699 |
GOTERM_BP_FAT | GO:0030216~keratinocyte differentiation | LOR, FLG, FOXN1, AHNAK2 | 3.70E-04 | 0.519046373 |
GOTERM_BP_FAT | GO:0009913~epidermal cell differentiation | LOR, FLG, FOXN1, AHNAK2 | 4.78E-04 | 0.67019525 |
GOTERM_BP_FAT | GO:0030855~epithelial cell differentiation | LOR, FLG, FOXN1, AHNAK2 | 0.003062052 | 4.219242042 |
GOTERM_CC_FAT | GO:0005856~cytoskeleton | LOR, NOS1, FLG, RPTN, MAP 2, KRT10, WASL, EPB41L4B, NEFL, NEFM, SPAG17 | 4.42E-04 | 0.488280071 |
GOTERM_CC_FAT | GO:0001533~cornified envelope | LOR, FLG, RPTN | 0.001040385 | 1.146550038 |
GOTERM_MF_FAT | GO:0005198~structural molecule activity | LOR, FLG, MAP 2, FLG2, KRT10, CLDN20, EPB41L4B, NEFL, NEFM | 1.15E-04 | 0.127152153 |
GOTERM_MF_FAT | GO:0005200~structural constituent of cytoskeleton | LOR, EPB41L4B, NEFL, NEFM | 7.83E-04 | 0.865579593 |