Table 1 Excluded studies

Zucchelli G, Bernardi F, Montebugnoli L,De SM [37].

Smoker patients included (<  20 cigarettes/day)

Windisch P, Sculean A, Klein F, et al. [38].

Smoker patients included

Sculean A, Windisch P, Chiantella GC, et al. [45].

Smoker patients included

Minabe M, Kodama T, Kogou T, et al. [39].

Smoker patients included (<  10 cigarettes/day)

Meyle J, Gonzales JR, Bödeker RH, et al. [40].

Smoker patients included (<  20 cigarettes/day)

Sanz M, Tonetti MS, Zabalegui I, et al. [41].

Smoker patients included (<  20 cigarettes/day)

Parashis A, Andronikaki-Faldami A, Tsiklakis K [42].

Smokers patients included

Jepsen J, Heinz BB, Jepse Kn, et al. [43].

Smoker patients included (<  20 cigarettes/day)

Hoffmann T, Richter S, Meyle J, et al. [44].

Smoker patients included (<  20 cigarettes/day)

Röllke L, Schacher B, Wohlfeil M, et al. [46].

Patients > 18 years included

Silvestri M, Ricci G, Rasperini G, Sartori S, Cattaneo V. [47].

Patients > 21 years included

Silvestri M, Sartori S, Rasperini G, et al. [48].

Patients > 21 years included

Farina R, Simonelli A, Rizzi A, et al. [49].

Chronic or aggressive periodontitis patients included

Ghezzi C, Ferrantino L, Bernardini L, Lencioni M, Masiero S. [50].

Chronic or aggressive periodontitis patients included

Pontoriero R, Wennström J, Lindhe J. [51]

Outcomes not reported in terms of early wound healing

Jaiswal R, Deo V. [52]

No intervention treatment (EMD) present

Sculean A, Donos N, Miliauskaite A, Arweiler N, Brecx M. [55]

Report long-term data of a previous included study [56]

Sculean A, Schwarz F, Miliauskaite A, et al. [53].

Report long-term data of a previous included study [56]

Sculean A, Donos N, Schwarz F, et al. [54].

Report long-term data of a previous included study [45]