Changes in salivary oxidative status, salivary cortisol, and clinical symptoms in female patients with temporomandibular disorders during occlusal splint therapy: a 3-month follow up

Table 2 Salivary OS biomarkers and cortisol concentrations in TMD patients and in specific TMD subgroups

Biomarker	time of day	TMD patients (n = 12)		Diagnosis (source)		Pain intensity
		TMD patients (n = 12)		MP (n = 6*)	DD(n = 6*)	Low (n = 6**)	High (n = 6**)
		Mean	(95% CI)	Mean	Mean	Mean	Mean
TAC⁺ (mmol/g)	AM	4.99	2.1–7.9	5.70	4.29	2.79	7.21
TAC⁺ (mmol/g)	PM	4.48	2.6–6.3	4.82	4.13	3.08	5.87
MDA⁺ (nmol/g)	AM	370.54	130.8–610.3	466.49	274.60	222.88	518.21
MDA⁺ (nmol/g)	PM	761.47	368.7–1154.2	750.69	772.24	498.24	1024.69
SOD⁺ (U/g)	AM	4408.31	2583.4–6233.2	3976.86	4839.77	3739.95	5076.68
SOD⁺ (U/g)	PM	3388.72	1882.2–4895.2	3006.02	3771.41	3238.30	3539.13
UA⁺ (μmol/g)	AM	661.72	208.1–1115.3	796.86	526.58	357.73	965.71
UA⁺ (μmol/g)	PM	613.07	288.9–937.18	687.96	538.19	402.90	823.25
SC (ng/ml)	AM	11.25	7.8–14.7	15.40	7.10	11.68	10.82
SC (ng/ml)	PM	3.09	1.8–4.4	3.75	2.43	3.77	2.42

⁺Concentrations Protein corrected
*pooled regardless of pain intensity; **pooled regardless of pathology source (diagnostic subgroup)
TAC Total antioxidant capacity, MDA Malondialdehyde, SOD Superoxide dismutase, UA Uric acid, SC Salivary cortisol, CI Confidence interval, TMD Temporomandibular disorders, DD Disc displacement, MP Myofascial pain

ISSN: 1472-6831