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Table 2 Summary of findings table

From: Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis

Impact of PRF on mandibular third molar surgery recovery

Patient or population: patients with mandibular third molar surgery recovery

Settings: outpatient

Intervention: PRF

Comparison: Non-PRF

Outcomes

Illustrative comparative risks* (95% CI)

Relative effect

(95% CI)

No of Participants

(studies)

Quality of the evidence

(GRADE)

Comments

Assumed risk

Corresponding risk

 

Non-PRF

PRF

    

Pain

Visual analog scale

Follow-up: 1-7 days

The mean pain in the control groups was 7.52

The mean pain in the intervention groups was 0.53 standard deviations lower

(1.02 to 0.05 lower)

 

322

(6 studies)

low1,2

 

Swelling

A flexible ruler

Follow-up: 1-7 days

The mean swelling in the control groups was 20.79

The mean swelling in the intervention groups was 0.55 standard deviations lower

(1.08 to 0.01 lower)

 

212

(4 studies)

moderate3

 

Trismus

Measuring the distance

Follow-up: 1-7 days

The mean trismus in the control groups was 24.35

The mean trismus in the intervention groups was 0.09 standard deviations lower

(0.68 lower to 0.5 higher)

 

131

(4 studies)

very low3,4,5

 

Alveolar osteitis

Follow-up: 2-90 days

179 per 1000

63 per 1000

(29 to 134)

RR 0.35

(0.16 to 0.75)

246

(3 studies)

low1,5

 

Osteoblastic activity

Follow-up: 28-90 days

The mean osteoblastic activity in the control groups was 4.29

The mean osteoblastic activity in the intervention groups was 0.05 higher

(0.44 lower to 0.55 higher)

 

68

(2 studies)

very low1,2,5

 

Soft tissue healing

Follow-up: 2-14 days

 

The mean soft tissue healing in the intervention groups was 1.03 higher

(0.32 lower to 2.38 higher)

 

70

(2 studies)

low1,4

 
  1. *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI)
  2. CI Confidence interval, RR Risk ratio;
  3. GRADE Working Group grades of evidence
  4. High quality: Further research is very unlikely to change our confidence in the estimate of effect
  5. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
  6. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
  7. Very low quality: We are very uncertain about the estimate
  8. 1 Having non-blinded study
  9. 2 The significant heterogeneity
  10. 3 No allocation concealment
  11. 4 Risk of bias
  12. 5 Pooled results included no effects