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Table 1 Characteristics of studies included in the network meta-analysis

From: Effect of non-surgical periodontal therapy on glycemic control of type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis

First author, year Country Inclusion criteria of T2DM T2DM duration (year) T2DM treatment Age (years) Female/male Intervention Control
Singh (2008) [25] India T2DM na na > 30 na A: SRP + Doxy (100 mg bid for day 1 and then 100 mg/day for 13 days) (n = 15) B: SRP (n = 15) No treatment (n = 15)
Gilowski (2012) [26] Poland T2DM diagnosed for > 6 months T: 4.0 (1.5–13.0) C: 5.0 (3.0–18.0) diet regimen, insulin, and or oral hypoglycemic drugs T: 57.6 ± 8.0 C: 56.0 ± 9.0 T: 10/ 7 C: 8/ 9 SRP + SDD (20 mg bid for 3 months) (n = 17) SRP + placebo (n = 17)
Moeintaghavi (2012) [27] Iran Diagnosis of T2DM with glycated HbA1c values over 7% na oral hypoglycemic drugs (no insulin) Female: 48.1 ± 3 Male: 52.48 ± 3 T: 13/ 9 C: 7/ 11 SRP (n = 22) No treatment (n = 18)
Gaikwad (2013) [28] India T2DM na Received antidiabetic therapy na 16/ 34 SRP + Doxy (100 mg/d for15 days) (n = 25) SRP (n = 25)
Pradeep (2013) [29] India Well-controlled type 2 DM (American Diabetic Association in 2011 and glycated hemoglobin levels) na na 30 - 50 18/ 20 SRP + SMV gel (1.2%) (n = 17) SRP + placebo (n = 18)
Santos (2013) [30] Brazil T2DM diagnosed > 5 years T: 6.3 ± 0.8 C: 6.8 ± 1.1 Diet: 1/ 0 Diet + insulin: 1/ 4 Diet + oral hypoglycemic agents: 14/ 14 Diet + oral hypoglycemic agents + insulin: 3/ 1 T: 50.3 ± 9.5 C: 53.9 ± 10.8 T: 15/ 4 C: 13/ 6 SRP + CHX gel (1%) + CHX solution (0.12%) rinse (bid/day for 60 days) (n = 19) SRP + placebo gel + placebo solutions rinse (n = 18)
Telgi (2013) [31] India T2DM na oral hypoglycemic agents 35 - 45 na A: SRP + 0.12% CHX mouthwash (once daily) and brush (twice daily) (n = 20) B: 0.12% CHX mouthwash (once daily) and brush (twice daily) (n = 20) brush (twice daily) (n = 20)
Macedo (2014) [11] Brazil T2DM diagnosed for >5 years and HbA1c >7 % > 5 na T: 49.4 ± 6.8 C: 48.1 ± 9 T: 9/ 6 C: 10/ 5 SRP + aPDT (10 mg/ml PC) + Doxy (100 mg bid for day 1 and then 100 mg/day for 13 days) (n = 15) SRP + Doxy (100 mg bid for day 1 and then 100 mg/day for 13 days) (n = 15)
Miranda (2014) [32] Brazil T2DM diagnosed for ≥ 5 years, HbA1c ≥ 6.5% ≤ 11% T: 8.0 ± 3.2 C: 7.4 ± 3.6 Diet and insulin supplementation or oral hypoglycemic agents T: 54.0 ± 8.2 C: 53.7 ± 8.0 T: 17/ 12 C: 9/ 18 SRP + MTZ + AMX (400/500 mg tid for 14 days) (n = 29) SRP + placebos (n = 27)
Tsalikis (2014) [33] Greece T2DM diagnosed for ≥ 1 year T: 11.8 ± 5.9 C: 10.2 ± 5.7 na T: 62.9 ± 10 C: 57.94 ±8.22 T: 13/ 18 C: 15/ 20 SRP+ Doxy (100 mg bid for day 1 and then 100 mg/day for 20 days) (n = 31) SRP + placebos (n = 35)
Wu (2015) [34] China T2DM diagnosed for > 1 year with no medication changes in the last 3 months T: 4.00 ± 1.76 C: 4.22 ± 1.57 na T: 54.09 ±6.57 C: 55.52 ±5.22 T: 12/11 C: 10/13 SRP + OHI (n = 23) OHI (n = 23)
Koçak (2016) [35] Turkey TDM2 (5.7 % ≤ glycated hemoglobin (HbA1c) ≤8.5 %) with no alteration in the diabetes treatment in the last year prior to the study Na na T: 51.7 ± 5.2 C: 53.1 ± 5.1 T: 15/15 C: 15/15 SRP + DL (n = 30) SRP (n = 30)
Kumari (2016) [10] India Well-controlled T2DM (American Diabetic Association in 2012 and glycated hemoglobin Levels) Na na 40-50 37/38 SRP + ATV gel (1.2%) (n = 30) SRP + placebo gel (n = 30)
Ramos (2016) [36] Brazil Type 2 DM diagnosed for > 5 years and HbA1c >7% >5 na T: 48.9 ± 9.5 C: 49.3 ± 7.4 T: 8/7 C: 8/7 SRP + aPDT (10 mg/ml PC) (n = 15) SRP + Doxy (100 mg bid for day 1 and then 100 mg/day for 13 days) (n = 15)
  1. SRP scaling and root planing, Doxy doxycycline, SDD subantimicrobial dose doxycycline, SMV simvastatin, CHX chlorhexidine, aPDT antimicrobial photodynamic therapy, AMX amoxicillin, MTZ metronidazole, ATV atorvastatin, DL diode laser, PC phenothiazine chloride solution, na not available