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Table 2 Outcomes of studies included in the network meta-analysis

From: Effect of non-surgical periodontal therapy on glycemic control of type 2 diabetes mellitus: a systematic review and Bayesian network meta-analysis

First author, year Inclusion criteria of chronic periodontitis Method of HbA1c% determination Initial HbA1c (%) (T vs. C) Outcome (ΔHbA1c%) (T vs. C) Outcome (ΔFPG) (T vs. C) Follow up (m) Adverse events (T vs. C)
Singh (2008) [25] Moderate to advanced periodontitis; at least 30% teeth with PPD ≥ 4 mm Liquid chromatography method TA: 8.3 ± 0.7 TB: 7.9 ± 0.7 C: 8.08 ± 0.7 TA: 0.8 ± 0.66 TB: 0.6 ± 0.66 C: -0.02 ± 0.72 TA: 4.16 ± 11.55 TB: 4 ± 14.45 3 No
Gilowski (2012) [26] Periodontitis; at least four nonadjacent sites with PPD ≥ 4 mm Turbidimetric inhibition immunoassay T: 6.7 (6.3–7.0) C: 6.2 (6.0–7.8) T: 0 ± 0.9 C: 0.1 ± 1.41   3 No
Moeintaghavi (2012) [27] Mild to moderate periodontitis (American Academy of Periodontology) Cobas Integra 700 apparatus (Roche Diagnostics, Germany) T: 8.15 ± 1.18 C: 8.72 ± 2.22 T: 0.74 ± 1.18 C: -0.25 ± 2.05 T: 17.5 ± 48.91 C: -9.78 ± 38.02 3 na
Gaikwad (2013) [28] Chronic generalized periodontitis na T: 8.38 ± 0.89 C: 8.06 ± 1.10 T: 1.38 ± 0.83 C: 0.95 ± 1.05 na 4 No
Pradeep (2013) [29] Chronic periodontitis; PPD ≥ 5 mm or CAL ≥ 4 mm and vertical bone loss ≥ 3mm on intraoral periapical radiographs na T: 6.66 ± 0.11 C: 6.71 ± 0.13 3m: T: 0.02 ± 0.12 C: 0.03 ± 0.13 6m: T: 0.01 ± 0.12 C:0.03 ± 0.13 9m: T: 0.03 ± 0.11 C: 0.05 ± 0.13 na 9 No
Santos (2013) [30] Generalized chronic periodontitis (Armitage 1999); at least 30% of sites with PPD and CAL ≥ 4 mm high-performance liquid chromatography T: 10 ± 2.41 C: 10.4 ± 2.9 3m: T: 0.78 ± 3.5 C: 0.68 ± 2.5 6m: T: 0.19 ± 2.9 C: 0.74 ± 4.1 12m: T: 0.35 ± 3.4 C: 1.4 ± 3.0 3m: T: 5.4 ± 65.09 C: 1.4 ± 77.31 6m: T: 5.5 ± 57.34 C: 15.4 ± 80.06 12m: T: 7.2 ± 72.37 C: 20.6 ± 79.15 12 T: 7, C: 12 reported taste perception change/ dry mouth/ staining
Telgi (2013) [31] mild to moderate periodontitis; PD: 4 – 5 mm na TA: 7.68 ± 0.63 TB: 7.56 ± 0.59 C: 7.74 ± 0.59 TA: 0.58 ± 0.27 TB: 0.25 ± 0.14 C: 0.004 ± 0.12 TA: 2.88 ± 1.07 TB: 1.29 ± 0.53 C: 0.42 ± 0.71 3 na
Macedo (2014) [11] Chronic periodontitis, at least one site with PPD ≥ 5 mm on each quadrant, two teeth with CAL ≥ 6 mm automated immunoturbidimetric method T: 8.6 ± 1.1 C: 8.0 ± 0.93 T: 0.87 ± 0.9 C: 0.41 ± 0.84 na 3 No
Miranda (2014) [32] the sites with PPD and CAL ≥ 4 mm, a minimum of six teeth with at least one site with PPD and CAL ≥ 5 mm, BOP high-performance liquid chromatography T: 8.53 ± 1.56 C: 8.99 ± 1.63 3m: T: -0.07 ± 1.83 C: 0.05 ± 1.67 6m: T: 0.04 ± 1.94 C: -0.08 ± 1.66 12m: T: -0.24 ± 2.54 C: 0.59 ± 1.81 3m: T: 5.46 ±38.30 C: 8.71 ± 40.41 6m: T: 6.19 ±34.01 C: 5.95 ± 45.50 12m:T:1.59± 36.53 C: 6.9 ± 47.09 12 Diarrhea: T: 7, C:3 Headache: T: 4, C: 1 Metallic taste: T: 4, C: 2 Nausea/Vomiting: T: 5, C: 2
Tsalikis (2014) [33] Moderate or advanced periodontitis; six pockets > 5mm, CAL > 3mm with radiographic bone loss A1CNow + Multitest HbA1c system T: 6.70 ± 0.61 C: 6.89 ± 0.60 3m: T: 0.08 ± 0.58 C: -0.07 ± 0.88 6m: T: 0.22 ± 0.67 C: 0.09 ± 0.77 na 6 C: 1 reported Dizziness and difficulty to swallow
Wu (2015) [34] mean CAL > 1mm (American Academy of Periodontology criteria) immunoturbidimetry T: 7.41 ± 0.20 C: 7.39 ± 0.16 3m: T: 0.01 ± 0.19 C: 0.01 ± 0.16 6m: T: 0.32 ± 0.17 C: 0.03 ± 0.17 na 6 na
Koçak (2016) [35] ≥ 8 sites with PPD ≥5mm na T: 6.9 ± 0.7 C: 6.5 ± 0.6 T: 0.41 ± 0.19 C: 0.22 ± 0.25 na 3 na
Kumari (2016) [10] Chronic periodontitis; PPD ≥ 5 mm or CAL ≥ 4 mm, and vertical bone loss ≥ 3 mm on intraoral periapical radiographs na T: 6.72 ± 0.13 C: 6.75 ± 0.12 3m: T: 0.04 ± 0.14 C: 0.03 ± 0.13 6m: T: 0.06 ± 0.13 C: 0.04 ± 0.13 9m: T: 0.07 ± 0.13 C: 0.06 ± 0.13 na 9 No
Ramos (2016) [36] At least one site with PPD ≥ 5 mm on each quadrant and two teeth with CAL ≥ 6 mm High pressure liquid chromatography T: 10.6 ± 1.99 C: 9.69 ± 1.68 T: 0.99 ± 1.00 C: 0.76 ± 0.73 na 3 No
  1. CAL clinical attachment loss, PPD probing pocket depth, BOP bleeding on probe, na not avail