Matsubara et al., 2012 [33]
|
DBA/2
|
Male
|
6–8
|
152
|
–
|
The combination of L. acidophilus and L. rhamnosus
|
0.2 ml suspension (109 probiotics)
|
Start 2 weeks before Candida inoculation, qd, 27d
|
Blank control
|
Candida counts
|
Nystatin
|
Ishijima et al., 2012 [34]
|
ICR
|
Female
|
6
|
55
|
Candida cotton swab to wipe oral mucosa
|
S. salivarius K12
|
0.05 ml suspension
|
24 h, 3 h before Candida inoculation, 3 h, 24 h, 27 h after Candida inoculation
|
Blank control
|
Candida counts, Oral infection score, Histology
|
Fluconazole
|
Elahi et al., 2005 [35]
|
DBA/2, BALB/c (Test data not published)
|
Male
|
6–8
|
25
|
Candida cotton swab to wipe oral mucosa
|
The combination of L. acidophilus and L. fermentum
|
0.2 ml suspension (109 probiotics)
|
Start 2 weeks before Candida inoculation, qd, 28d
|
Blank control
|
Candida counts, IL-4, IL-12, IFN-γ, NO
|
Ishijima et al., 2014 [36]
|
ICR
|
Female
|
6
|
73
|
Candida cotton swab to wipe oral mucosa
|
E. faecalis
|
0.05 ml suspension
|
24 h, 3 h before Candida inoculation, 3 h, 24 h, 27 h after Candida inoculation
|
Blank control
|
Candida counts, Oral infection score, Histology
|
Fluconazole
|
Leao et al., 2018 [37]
|
Wistar mice (immunosupp-ressed by intraperitoneal injection with dexamethasone (65 mg/kg))
|
Male
|
11–12
|
90
|
Candida cotton swab was left for 80 min under the tongue
|
L. rhamnosus
|
100 μL suspension (10 9 cells/mL)
|
2 weeks before Candida inoculation; Probiotics intake when Candida inoculation
|
Blank control
|
Candida counts, Inflammatory infiltrate score, The cytokines levels (TNF-α, IL-1β, IL-4, IL-6, IL-10, IL-12, and INF-γ)
|