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Table 1 Comparison of the proportion of CD11c+ DCs in various mucosal lymphoid tissues

From: Nasal double DNA adjuvant induces salivary FimA-specific secretory IgA antibodies in young and aging mice and blocks Porphyromonas gingivalis binding to a salivary protein

  % of CD11c+ DCs
Mice DA NALT SLGs SMGs PGLNs
8 weeks + 6.7 ± 1.1 * 11.2 ± 2.5 * 2.7 ± 1.3 14.1 ± 3.9 *
1.9 ± 0.3 4.1 ± 1.4 1.9 ± 0.6 2.5 ± 0.3
48 weeks + 5.9 ± 1.0 * 9.7 ± 2.1 * 2.5 ± 1.0 12.2 ± 4.1 *
1.2 ± 0.4 2.8 ± 0.9 1.4 ± 0.5 1.9 ± 0.3
  1. The proportions of CD11c+ DCs in mucosal inductive tissues (NALT), salivary glands (SLGs, SMGs) and periglandular lymph nodes (PGLNs) of mice given nasal rFimA plus a combination of pFL and CpG ODN (n = 20) or rFimA alone (n = 20) were examined. Young (8 weeks) and aging (48 weeks) mice were nasally immunized weekly for three consecutive weeks with 50 μg rFimA, 50 μg pFL, and 10 μg CpG ODN, respectively. One week after the final immunization, mononuclear cells from NALT, SLGs, SMGs and PGLNs were stained with FITC-anti-CD11c mAbs and subjected to flow cytometry analysis by FACSVerse®. *p < 0.05 when compared with immunized mice with rFimA alone