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Table 1 The Invading tumour front grading system used to generate total IFG score, as developed by Bryne et al. [10]

From: Assessment of proliferating cell nuclear antigen (PCNA) expression at the invading front of oral squamous cell carcinoma

Morphological feature Score
1 2 3 4
Degree of keratinisation Highly keratinised (> 50% of the cells) Moderately keratinised (20–50% of the cells) Minimal keratinisation (5–20% of the cells) No keratinisation (0–5% of the cells)
Nuclear polymorphism Little nuclear polymorphism (> 75% mature cells) Moderately abundant nuclear polymorphism (50–75% mature cells) Abundant nuclear polymorphism (25–50% mature cells) Extreme nuclear polymorphism (0–25% mature cells)
Pattern of invasion Pushing, well delineated infiltrating borders Infiltrating, solid cords, bands and /or strands Small groups of cords of infiltrating cells (n > 15) Marked and widespread cellular dissociation in small groups and /or in single cells (n < 15)
Host response (inflammatory cell infiltration) Marked Moderate Slight None