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Table 1 The Invading tumour front grading system used to generate total IFG score, as developed by Bryne et al. [10]

From: Assessment of proliferating cell nuclear antigen (PCNA) expression at the invading front of oral squamous cell carcinoma

Morphological feature

Score

1

2

3

4

Degree of keratinisation

Highly keratinised (> 50% of the cells)

Moderately keratinised (20–50% of the cells)

Minimal keratinisation (5–20% of the cells)

No keratinisation (0–5% of the cells)

Nuclear polymorphism

Little nuclear polymorphism (> 75% mature cells)

Moderately abundant nuclear polymorphism (50–75% mature cells)

Abundant nuclear polymorphism (25–50% mature cells)

Extreme nuclear polymorphism (0–25% mature cells)

Pattern of invasion

Pushing, well delineated infiltrating borders

Infiltrating, solid cords, bands and /or strands

Small groups of cords of infiltrating cells (n > 15)

Marked and widespread cellular dissociation in small groups and /or in single cells (n < 15)

Host response (inflammatory cell infiltration)

Marked

Moderate

Slight

None