Evaluation of the efficacy of casein phosphopeptide-amorphous calcium phosphate on remineralization of white spot lesions in vitro and clinical research: a systematic review and meta-analysis

Table 1 Main characteristics of included trials in clinical research

First author (Year)	Country	Sample (Mean age)	Follow up	Location of lesions	Male (n, %)	CPP-ACP Group			Control Group			Outcome report
						Sample size	Type of intervention	Frequency	Sample size	Type of intervention	Frequency
Bröchner 2014 [26]	Denmark	15.20 (n.r)^s years	4 weeks	buccal surfaces	45	22	tooth mousse	qd	28	standard fluoride toothpaste	bid	Fluorescence loss (%)
Sitthisettapong 2014 [27]	Thailand	37.51 (2.93)^s months	1 year	labial surface	54	40	fluoride toothpaste and tooth mousse	qd	39	fluoride toothpaste and placebo paste	qd	Fluorescence loss (%)

Explanations: “n.r” = “not reported,” “qd” = “once daily,” “bid” = “twice daily,” ^s Mean (standard deviation)

ISSN: 1472-6831