Effect of bisphosphonate treatment of titanium surfaces on alkaline phosphatase activity in osteoblasts: a systematic review and meta-analysis

Table 2 Study quality assessment. 1) stability of bisphosphonate coating, 2) ALP measurement quality, 3) description of coating procedure, 4) availability of original data, 5) surface roughness parameters, 6) contact angle measurement, 7) appropriate statistical analysis, 8) performance of at least three repetitions per experiment

	1	2	3	4	5	6	7	8	Study quality
Bigi et al. [40]	No	No	Yes	Yes	Yes	No	Yes	Yes	Medium
Boanini et al. [41]	No	No	Yes	Yes	Yes	No	Yes	No	Medium
Boanini et al. [42]	Yes	No	Yes	Yes	Yes	No	Yes	No	Medium
Hu et al. [44]	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Low
Jeon et al. [43]	No	Yes	Yes	No	No	No	Yes	Yes	Medium
Kim et al. [45]	Yes	Yes	Yes	No	No	No	Yes	Yes	Medium
Kim et al. [46]	No	Yes	Yes	Yes	No	No	Yes	No	Medium
Moon et al. [47]	Yes	Yes	Yes	No	No	Yes	Yes	Yes	Low
Mu et al. [48]	Yes	Yes	Yes	Yes	Yes	No	No	No	Medium
Yoshinari et al. [49]	No	Yes	Yes	No	Yes	No	Yes	No	Medium
Zheng et al. [50]	Yes	Yes	Yes	No	Yes	Yes	Yes	Yes	Low

ISSN: 1472-6831