Table 2 Studies that were included and their suitable efficacy level

Nagao et al. 2006 [65]

Walter et al. 2009 [66]

Pajnigara et al. 2016 [67]

Grimrad et al.2009 [68]

Walter et al. 2012 [69]

Walter et al.2016 [70]

Micsh et al. 2006 [42]

Ex vivo

Walter et al. 2010 [71]

Gupta SJ et al. 2014 [72]

Anter et al.2016 [73]

Naitoh et al. 2006 [63]

Case report

De Faria et al.2012 [74]

Khosropana et al.2015 [75]

Nikolic-Jakoba et al.2016 [6]

Nagao et al.2007 [62]

Did no check for periodontitis

Fiejo et al. 2012 [76]

Bhavsar et al. 2016 [77]

Haas et al. 2018 [78]

Vandenberghe et al. 2007 [47]

Ex vivo

Walter et al. 2012 [69]

Pajnigara et al. 2017 [79]

Choi et al. 2018 [80]

Mol et al. 2008 [43]

Ex vivo

Raichur et al. 2012 [81]

Dutra et al. 2017 [82]

Woelber et al. 2018 [83]

Vandenberghe et al. 2008 [46]

Ex vivo

Marinescu et al. 2013 [84]

Nemoto et al. 2018 [85]

Noujeim et al. 2009 [44]

Ex vivo

Qiao et al. 2013 [86]

Leung et al. 2010 [60]

Ex vivo

Haghgoo et al.2014 [87]

Evangelista et al.2010 [58]

Addressed naturally occurring dehiscence and fenestration in patients with malocclusions

Banodkar et al. 2015 [88]

Ferreira et al.2013 [57]

Study targets bone coverage

Cimbaljevic et al. 2015 [89]

DG Pour et al. 2015 [61]

Does not involve patients with periodontitis

Darby et al. 2015 [90]

AlShaer et al. 2013 [55]

Does not belong to any level of efficacy

Li F et al. 2015 [91]

Fliener et al. 2013 [40]

Ex vivo

Guo et al. 2016 [92]

Kamuroglu et al. 2013 [41]

Ex vivo

Zhu et al. 2016 [93]

Amorfini et al.2014 [54]

Does not belong to any level of efficacy

Suphanantachat et al. 2017 [94]

Sun L et al. 2015 [59]

Excluded patients with periodontal diseases

Padmanabhan et al. 2017 [95]

Yang et al. 2015 [53]

Does not belong to any level of efficacy

Zhang et al. 2018 [96]

Bagis et al. 2015 [38]

Ex vivo

Takeshita et al. 2015 [28]

Ex vivo

Kolsuz et al. 2015 [48]

Ex vivo

Kamburoğlu et al. 2015 [49]

Animal study and not plaque-induced periodontitis

Deng et al. 2015 [64]

Not in English Language

Lim et al. 2016 [51]

Does not belong to any level of efficacy

Al-Zahrani et al. 2017 [56]

Targets bone density in aggressive periodontitis and normal patients

Ozcan et al.2017 [52]

Does not belong to any level of efficacy

Almeida et al.2017 [39]

Ex vivo

Salineiro et al.2017 [45]

Ex vivo

Elashiry et al. 2018 [50]

Not plaque-induced periodontitis