Skip to main content

Table 1 General characteristics of the included studies

From: Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

Author (year) Country Intervention Controls Sample size test/control Gender Mean age
(range)
Type of RAS Follow-up(days)
Sharma et al (2018) [18] India Topical Doxycycline G1: 5% Amlexanox;
G2: 0.1% Triamcinolone acetonide
G3: Benzocaine gel
G4: placebo gel
10/40 50% 26.5 Minor 10
Thriveni et al, (2018) [17] India Topical Doxycycline Placebo 100 mg (starch, lactose, sodium starch glycolate, talc, magnesium stearate) 20/20 NA NA Minor 10
Chandak et al, (2017) [19] India Topical Doxycycline 0.1% triamcinolone acetonide paste 15/15 M = 14
F = 16
15–40 Minor 7
Vijayabala et al. (2013) [4] India Topical Doxycycline Placebo 100 mg (starch, lactose, sodium starch glycolate, talc, magnesium stearate) 25/25 M = 30
F = 20
25.14 Minor 10
Ylikontiola (1997) [13] Finland Topical Doxycycline Placebo (calcii gluconase) 16/15 M = 4
F = 27
23–63 Minor 10
  1. F Female, M Male, NA Not Available