Table 2 Drug formulation and the main outcomes of the included studies
Study | Formulation and dose | Outcome measures | Adverse effects | Main outcomes |
|---|---|---|---|---|
Sharma et al (2018) [18] | Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline | Pain Size of the ulcer Erythema | None | On day 4, Doxycycline and Triamcinolone acetonide groups showed better efficacy in reducing pain and ulcer size compared to other groups, but without any significant differences between the two groups. |
Thriveni et al, (2018) [17] | Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline | Pain Healing time | NA | Doxycycline hyclate showed a significant reduction in pain at follow-up visits as compared to placebo group (P < 0.001). |
Chandak et al, (2017) [19] | Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline | Pain Healing time | None | Healing of the ulcer was significantly faster in doxycycline group compared to triamcinolone ointment (P < 0.01). However, there was no a significant difference in pain reduction between the two groups (P > 0.05). |
Vijayabala et al. (2013) [4] | Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline | pain Healing time | 8 patients reported transient bitter taste | A single application of doxycycline hyclate was significantly more effective in alleviating pain and reducing healing time as compared to placebo group (P < 0.001) |
Ylikontiola (1997) [13] | Doxycycline 150 mg was crushed and mixed with saline. One drop of isobutyl cyanoacrylate as adhesive | Pain | NA | A significant reduction in pain in doxycycline group from day 2 to day 7 as compared to control group (P < 0.05). |