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Table 2 Drug formulation and the main outcomes of the included studies

From: Single application of topical doxycycline in management of recurrent aphthous stomatitis: a systematic review and meta-analysis of the available evidence

Study Formulation and dose Outcome measures Adverse
effects
Main outcomes
Sharma et al (2018) [18] Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline Pain
Size of the ulcer
Erythema
None On day 4, Doxycycline and Triamcinolone acetonide groups showed better efficacy in reducing pain and ulcer size compared to other groups, but without any significant differences between the two groups.
Thriveni et al, (2018) [17] Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline Pain
Healing time
NA Doxycycline hyclate showed a significant reduction in pain at follow-up visits as compared to placebo group (P < 0.001).
Chandak et al, (2017) [19] Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline Pain
Healing time
None Healing of the ulcer was significantly faster in doxycycline group compared to triamcinolone ointment (P < 0.01).
However, there was no a significant difference in pain reduction between the two groups (P > 0.05).
Vijayabala et al. (2013) [4] Topical, Doxycycline Hyclate 100 mg was crushed and mixed with denture adhesive and saline pain
Healing time
8 patients reported transient bitter taste A single application of doxycycline hyclate was significantly more effective in alleviating pain and reducing healing time as compared to placebo group (P < 0.001)
Ylikontiola (1997) [13] Doxycycline 150 mg was crushed and mixed with saline. One drop of isobutyl cyanoacrylate as adhesive Pain NA A significant reduction in pain in doxycycline group from day 2 to day 7 as compared to control group (P < 0.05).
  1. NA Not Available