Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomised, double-blind, placebo-controlled trial

Kang, Mi-Sun; Lee, Dong-Suk; Lee, Seung-Ah; Kim, Myoung-Suk; Nam, Seoul-Hee

doi:10.1186/s12903-020-01231-2

Table 4 Gram-negative bacterial measurements in subgingival plaque at baseline, 4, and 8 weeks N = 68

From: Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomised, double-blind, placebo-controlled trial

Variables	Timepoint	Mean (Log₁₀ DNA copy N) ± SD			Delta mean (Log₁₀ DNA copy N) ± SD
Variables	Timepoint	Probiotic (n = 34)	Placebo (n = 34)	P-value^#	Probiotic (n = 34)	Placebo (n = 34)	P-value^#
Aggregatibacter actinomycetemcomitans	Baseline	0.07 ± 0.42	0.00 ± 0.00	NS
	4 weeks	0.15 ± 0.90	0.00 ± 0.00	NS	0.08 ± 0.48	0.00 ± 0.00	NS
	8 weeks	0.13 ± 0.76	0.06 ± 0.35	NS	0.06 ± 0.35	0.06 ± 0.35	NS
Campylobacter rectus	Baseline	0.54 ± 1.06	0.68 ± 1.18	NS
	4 weeks	0.91 ± 1.27	1.31 ± 1.70^a	NS	0.37 ± 1.40	0.62 ± 1.27	NS
	8 weeks	1.59 ± 1.67^a	2.03 ± 2.08^a	NS	1.05 ± 1.68	1.35 ± 1.58	NS
Eikenella corrodens	Baseline	0.32 ± 0.68	0.30 ± 0.89	NS
	4 weeks	0.27 ± 0.61	0.38 ± 0.79	NS	−0.05 ± 0.97	0.08 ± 0.70	NS
	8 weeks	0.50 ± 0.96	0.86 ± 1.17^a	NS	0.18 ± 0.93	0.57 ± 1.03	NS
Fusobacterium nucleatum	Baseline	4.49 ± 1.09	4.05 ± 1.05	NS
	4 weeks	4.41 ± 1.09	4.64 ± 1.05^a	NS	−0.08 ± 1.20	0.59 ± 1.10	.035
	8 weeks	5.12 ± 0.84^a	5.25 ± 1.07^a	NS	0.63 ± 1.16	1.20 ± 0.91	.030
Porphyromonas gingivalis	Baseline	0.17 ± 0.82	0.26 ± 0.72	NS
	4 weeks	0.14 ± 0.73	0.48 ± 1.29	NS	−0.03 ± 1.04	0.21 ± 1.03	NS
	8 weeks	0.15 ± 0.62	0.69 ± 1.82	NS	− 0.02 ± 0.46	0.43 ± 1.32	NS
Prevotella intermedia	Baseline	0.62 ± 1.27	0.67 ± 1.24	NS
	4 weeks	0.75 ± 1.22	0.77 ± 1.56	NS	0.13 ± 1.14	0.10 ± 0.86	NS
	8 weeks	1.23 ± 1.58^a	1.20 ± 1.93^a	NS	0.61 ± 1.32	0.54 ± 1.05	NS
Prevotella nigrescens	Baseline	1.73 ± 1.48	1.28 ± 1.22	NS
	4 weeks	2.04 ± 1.51	1.91 ± 1.53^a	NS	0.32 ± 1.75	0.63 ± 1.50	NS
	8 weeks	2.82 ± 1.55^a	2.72 ± 1.56^a	NS	1.09 ± 1.61	1.44 ± 1.52	NS
Tannerella forsythia	Baseline	0.53 ± 1.22	0.90 ± 1.38	NS
	4 weeks	0.66 ± 1.17	1.36 ± 1.90	NS	0.13 ± 1.43	0.46 ± 1.43	NS
	8 weeks	0.99 ± 1.79	1.83 ± 2.29^a	NS	0.46 ± 1.60	0.93 ± 1.59	NS
Treponema denticola	Baseline	0.50 ± 1.09	0.67 ± 1.34	NS
	4 weeks	1.01 ± 1.59	1.06 ± 1.79	NS	0.51 ± 1.71	0.39 ± 1.37	NS
	8 weeks	1.77 ± 1.87^a	1.49 ± 2.11^a	NS	1.27 ± 1.55	0.82 ± 1.43	NS

Values are mean ± standard deviation
^aSignificant differences from baseline
^#Significant differences between the groups: P < 0.05, significant (bold); not significant (NS)

Back to article page

ISSN: 1472-6831

Contact us

Submission enquiries: bmcoralhealth@biomedcentral.com
General enquiries: ORSupport@springernature.com

BMC Oral Health

Contact us