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Table 4 Gram-negative bacterial measurements in subgingival plaque at baseline, 4, and 8 weeks N = 68

From: Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomised, double-blind, placebo-controlled trial

Variables Timepoint Mean (Log10 DNA copy N) ± SD Delta mean (Log10 DNA copy N) ± SD
Probiotic
(n = 34)
Placebo
(n = 34)
P-value# Probiotic
(n = 34)
Placebo
(n = 34)
P-value#
Aggregatibacter actinomycetemcomitans Baseline 0.07 ± 0.42 0.00 ± 0.00 NS    
4 weeks 0.15 ± 0.90 0.00 ± 0.00 NS 0.08 ± 0.48 0.00 ± 0.00 NS
8 weeks 0.13 ± 0.76 0.06 ± 0.35 NS 0.06 ± 0.35 0.06 ± 0.35 NS
Campylobacter rectus Baseline 0.54 ± 1.06 0.68 ± 1.18 NS    
4 weeks 0.91 ± 1.27 1.31 ± 1.70a NS 0.37 ± 1.40 0.62 ± 1.27 NS
8 weeks 1.59 ± 1.67a 2.03 ± 2.08a NS 1.05 ± 1.68 1.35 ± 1.58 NS
Eikenella corrodens Baseline 0.32 ± 0.68 0.30 ± 0.89 NS    
4 weeks 0.27 ± 0.61 0.38 ± 0.79 NS −0.05 ± 0.97 0.08 ± 0.70 NS
8 weeks 0.50 ± 0.96 0.86 ± 1.17a NS 0.18 ± 0.93 0.57 ± 1.03 NS
Fusobacterium nucleatum Baseline 4.49 ± 1.09 4.05 ± 1.05 NS    
4 weeks 4.41 ± 1.09 4.64 ± 1.05a NS −0.08 ± 1.20 0.59 ± 1.10 .035
8 weeks 5.12 ± 0.84a 5.25 ± 1.07a NS 0.63 ± 1.16 1.20 ± 0.91 .030
Porphyromonas gingivalis Baseline 0.17 ± 0.82 0.26 ± 0.72 NS    
4 weeks 0.14 ± 0.73 0.48 ± 1.29 NS −0.03 ± 1.04 0.21 ± 1.03 NS
8 weeks 0.15 ± 0.62 0.69 ± 1.82 NS − 0.02 ± 0.46 0.43 ± 1.32 NS
Prevotella intermedia Baseline 0.62 ± 1.27 0.67 ± 1.24 NS    
4 weeks 0.75 ± 1.22 0.77 ± 1.56 NS 0.13 ± 1.14 0.10 ± 0.86 NS
8 weeks 1.23 ± 1.58a 1.20 ± 1.93a NS 0.61 ± 1.32 0.54 ± 1.05 NS
Prevotella nigrescens Baseline 1.73 ± 1.48 1.28 ± 1.22 NS    
4 weeks 2.04 ± 1.51 1.91 ± 1.53a NS 0.32 ± 1.75 0.63 ± 1.50 NS
8 weeks 2.82 ± 1.55a 2.72 ± 1.56a NS 1.09 ± 1.61 1.44 ± 1.52 NS
Tannerella forsythia Baseline 0.53 ± 1.22 0.90 ± 1.38 NS    
4 weeks 0.66 ± 1.17 1.36 ± 1.90 NS 0.13 ± 1.43 0.46 ± 1.43 NS
8 weeks 0.99 ± 1.79 1.83 ± 2.29a NS 0.46 ± 1.60 0.93 ± 1.59 NS
Treponema denticola Baseline 0.50 ± 1.09 0.67 ± 1.34 NS    
4 weeks 1.01 ± 1.59 1.06 ± 1.79 NS 0.51 ± 1.71 0.39 ± 1.37 NS
8 weeks 1.77 ± 1.87a 1.49 ± 2.11a NS 1.27 ± 1.55 0.82 ± 1.43 NS
  1. Values are mean ± standard deviation
  2. aSignificant differences from baseline
  3. #Significant differences between the groups: P < 0.05, significant (bold); not significant (NS)