Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomised, double-blind, placebo-controlled trial

Table 5 Gram-positive bacterial measurements in subgingival plaque at baseline, 4, and 8 weeks N = 68

Variables	Timepoint	Mean (Log₁₀ DNA copy N) ± SD			Delta mean (Log₁₀ DNA copy N) ± SD
Variables	Timepoint	Probiotic (n = 34)	Placebo (n = 34)	P -value^#	Probiotic (n = 34)	Placebo (n = 34)	P -value^#
Actinomyces viscosus	Baseline	5.42 ± 0.58	4.99 ± 0.64	.003
	4 weeks	5.22 ± 0.48	5.36 ± 0.42^a	NS	−0.20 ± 0.62	0.37 ± 0.64	.001
	8 weeks	5.69 ± 0.48	5.51 ± 0.46^a	NS	0.27 ± 0.74	0.52 ± 0.54	NS
Enterococcus faecalis	Baseline	0.12 ± 0.48	0.07 ± 0.33	NS
	4 weeks	0.09 ± 0.38	0.20 ± 0.55	NS	−0.03 ± 0.63	0.13 ± 0.50	NS
	8 weeks	0.21 ± 0.60	0.19 ± 0.75	NS	0.09 ± 0.77	0.12 ± 0.83	NS
Eubacterium nodatum	Baseline	0.26 ± 0.68	0.39 ± 1.07	NS
	4 weeks	0.21 ± 0.55	0.43 ± 1.09	NS	−0.05 ± 0.89	0.04 ± 1.07	NS
	8 weeks	0.65 ± 1.46	0.72 ± 1.42^a	NS	0.39 ± 1.53	0.33 ± 1.30	NS
Group of Streptococcus	Baseline	4.95 ± 0.75	4.58 ± 0.74	.025
	4 weeks	4.39 ± 0.56^a	4.50 ± 0.52	NS	−0.57 ± 0.73	−0.08 ± 0.71	.008
	8 weeks	4.95 ± 0.72	4.75 ± 0.65	NS	− 0.01 ± 0.98	0.17 ± 0.60	NS
Parvimonas micra	Baseline	1.58 ± 1.19	1.26 ± 1.18	NS
	4 weeks	1.52 ± 1.32	1.61 ± 1.40	NS	−0.06 ± 1.72	0.36 ± 1.21	NS
	8 weeks	2.35 ± 1.41^a	2.30 ± 1.46^a	NS	0.77 ± 1.63	1.05 ± 0.91	NS
Staphylococcus aureus	Baseline	0.69 ± 0.91	0.41 ± 0.84	NS
	4 weeks	0.61 ± 0.95	0.53 ± 0.90	NS	−0.08 ± 1.35	0.12 ± 1.31	NS
	8 weeks	0.40 ± 0.82	0.97 ± 1.12^a	.023	− 0.29 ± 1.26	0.56 ± 1.23	.014
Streptococcus mutans	Baseline	0.41 ± 0.80	0.11 ± 0.39	NS
	4 weeks	0.37 ± 0.88	0.29 ± 0.69	NS	−0.04 ± 0.94	0.18 ± 0.82	NS
	8 weeks	0.54 ± 0.96	0.46 ± 0.90	NS	0.13 ± 0.97	0.36 ± 1.03	NS

Values are mean ± standard deviation
^aSignificant differences from baseline
^#Significant differences between the groups: P < .05, significant (bold); not significant (NS)

ISSN: 1472-6831