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Table 5 Gram-positive bacterial measurements in subgingival plaque at baseline, 4, and 8 weeks N = 68

From: Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomised, double-blind, placebo-controlled trial

Variables Timepoint Mean (Log10 DNA copy N) ± SD Delta mean (Log10 DNA copy N) ± SD
Probiotic
(n = 34)
Placebo
(n = 34)
P -value# Probiotic
(n = 34)
Placebo
(n = 34)
P -value#
Actinomyces viscosus Baseline 5.42 ± 0.58 4.99 ± 0.64 .003    
4 weeks 5.22 ± 0.48 5.36 ± 0.42a NS −0.20 ± 0.62 0.37 ± 0.64 .001
8 weeks 5.69 ± 0.48 5.51 ± 0.46a NS 0.27 ± 0.74 0.52 ± 0.54 NS
Enterococcus faecalis Baseline 0.12 ± 0.48 0.07 ± 0.33 NS    
4 weeks 0.09 ± 0.38 0.20 ± 0.55 NS −0.03 ± 0.63 0.13 ± 0.50 NS
8 weeks 0.21 ± 0.60 0.19 ± 0.75 NS 0.09 ± 0.77 0.12 ± 0.83 NS
Eubacterium nodatum Baseline 0.26 ± 0.68 0.39 ± 1.07 NS    
4 weeks 0.21 ± 0.55 0.43 ± 1.09 NS −0.05 ± 0.89 0.04 ± 1.07 NS
8 weeks 0.65 ± 1.46 0.72 ± 1.42a NS 0.39 ± 1.53 0.33 ± 1.30 NS
Group of
Streptococcus
Baseline 4.95 ± 0.75 4.58 ± 0.74 .025    
4 weeks 4.39 ± 0.56a 4.50 ± 0.52 NS −0.57 ± 0.73 −0.08 ± 0.71 .008
8 weeks 4.95 ± 0.72 4.75 ± 0.65 NS − 0.01 ± 0.98 0.17 ± 0.60 NS
Parvimonas micra Baseline 1.58 ± 1.19 1.26 ± 1.18 NS    
4 weeks 1.52 ± 1.32 1.61 ± 1.40 NS −0.06 ± 1.72 0.36 ± 1.21 NS
8 weeks 2.35 ± 1.41a 2.30 ± 1.46a NS 0.77 ± 1.63 1.05 ± 0.91 NS
Staphylococcus aureus Baseline 0.69 ± 0.91 0.41 ± 0.84 NS    
4 weeks 0.61 ± 0.95 0.53 ± 0.90 NS −0.08 ± 1.35 0.12 ± 1.31 NS
8 weeks 0.40 ± 0.82 0.97 ± 1.12a .023 − 0.29 ± 1.26 0.56 ± 1.23 .014
Streptococcus mutans Baseline 0.41 ± 0.80 0.11 ± 0.39 NS    
4 weeks 0.37 ± 0.88 0.29 ± 0.69 NS −0.04 ± 0.94 0.18 ± 0.82 NS
8 weeks 0.54 ± 0.96 0.46 ± 0.90 NS 0.13 ± 0.97 0.36 ± 1.03 NS
  1. Values are mean ± standard deviation
  2. aSignificant differences from baseline
  3. #Significant differences between the groups: P < .05, significant (bold); not significant (NS)