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Table 3 Differentially expressed proteins in GCF at T1, T3, and T6 during orthodontic treatment when compared to T0 (pre-treatment). There was a change in the expression of 16 proteins in the GCF. Increased and decreased protein abundance (PA) of significant proteins are represented in the form of ↑ and ↓ (Student’s T-test, p-value ≤0.05)

From: Label-free quantitative proteomic analysis of gingival crevicular fluid to identify potential early markers for root resorption

Protein name Gene name Accession number (SwissProt) pI/MW (kDa) Sequest score Peptide matched (% sequence coverage) Fold change; differential protein abundance (↑/↓) Student’s t-test; p-value
T1 T3 T6
Angiotensinogen AGT P01019 6.32/53.12 2.21 2.47 1.03↓ 1.04↓ 0.98↓ 0.03
Apolipoprotein D APOD P05090 5.15/21.26 2.11 5.82 1.20↓ 1.13↓ 0.99↓ 0.05
Beta-2-glycoprotein 1 APOH P02749 7.97/38.27 171.74 35.36 1.18↓ 1.10↓ 1.12↓ 0.02
Heat shock 70 kDa protein 1A HSPA1A P0DMV8 5.66/70.01 96.86 12.79 1.14↓ 0.99↑ 1.02↑ 0.01
Hemoglobin subunit beta HBB P68871 7.28/15.99 429.06 89.80 1.15↓ 1.14↓ 1.07↓ 0.03
Histidine-rich glycoprotein HRG P04196 7.5/59.54 12.46 2.67 1.13↓ 1.05↓ 1.18↓ 0.02
Ig heavy variable 4–34 IGHV4–34 P06331 8.28/16.22 16.36 10.96 1.02↓ 0.99↑ 1.01↑ 0.03
Ig kappa variable 3–20 IGKV3–20 P01619 8.48/11.77 187.22 31.19 1.11↓ 1.08↓ 1.01↑ 0.03
Ig heavy variable 3–11 IGHV3–11 P01762 9.72/13.46 19.17 15.57 1.08↓ 1.03↓ 1.12↓ 0.04
Ig heavy constant gamma 1 IGHG1 P01857 8.19/36.08 848.34 51.52 1.12↓ 1.07↓ 0.99↓ 0.03
Ig J chain IGJ P01591 5.24/18.09 15.71 16.35 0.98↑ 0.98↑ 1.05↑ 0.03
Thymidine phosphorylase TYMP P19971 5.53/50.37 14.68 2.87 1.07↓ 0.97↑ 0.83↓ 0.03
Protein S100-A9 S100A9 P06702 6.13/13.23 44.48 24.56 0.97↑ 0.95↑ 1.07↑ 0.02
Thymosin beta-4 TMSB4X P62328 5.06/5.05 143.02 54.55 1.02↓ 1.00↓ 1.04↓ 0.05
Zinc-alpha-2-glycoprotein AZGP1 P25311 6.05/34.24 108.53 19.46 0.95↑ 0.90↑ 1.13↑ 0.04
Vitronectin VTN P04004 5.8/54.27 239.34 23.85 0.99↑ 1.00↓ 1.064↑ 0.04