Table 1 General Characteristics of studies included

1

Sahu et al. 2019 [20]

RCT (SM)

25–55

NM

20 patients (40 sites)

A. SRP alone (20 sites)

B. SRP plus CHX chip (20 sites)

PERIOCOL-CG™

(2.5 mg CHX from a 20% CHX solution in fish collagen membrane)

PI,GI,SBI,PPD, RAL

3 months (0,1,3)

2

Singh et al. 2018 [21]

RCT (SM)

35–55

15/5

20 patients

(40 sites)

A. SRP alone (20 sites)

B. SRP plus CHX chip (20 sites)

NM

PI, m-BI, PPD, CAL, BANA

3 months (0,1,3)

3

Divya et al. 2018 [22]

RCT (P)

NM

NM

122 sites

A. SRP alone (61 sites)

B. SRP plus CHX chip (61 sites)

PERIOCOL-CG™

(2.5 mg CHX from a 20% CHX solution in fish collagen membrane)

GI, PPD,CAL

9 months (0,1,3,6,9)

4

Singh et al. 2017 [23]

RCT (SM)

30–50

22/18

40 patients (120 sites)

A. SRP alone (40 sites)

B. SRP plus CHX chip (40 sites)

C. SRP plus Turmeric Chip (40 sites)

PERIOCOL-CG™

(2.5 mg CHX from a 20% CHX solution in fish collagen membrane)

PI, GI, PPD, RAL

3 months (0,1,3)

5

Lecic et al. 2016 [24]

RCT (SM)

21–52

8/7

15 patients (120 sites)

A.SRP alone (60 sites)

B. SRP pus CHX gel (20 sites)

C.SRP plus CHX irrigation (20 sites)

D. SRP plus CHX chip (20 sites)

Perio Chip®, Perioproducts, Jerusalem, Israel

PI, BOP, PPD, CAL

3 months (0,1,3)

6

John et al., 2015 [25]

RCT (SM)

35–56

11/9

20 patients (40 sites)

A. SRP alone (20 sites)

B. SRP plus CHX chip (20 sites)

2.5 mg CHX from a 20% CHX solution in fish collagen membrane

PI, GI, PPD, CAL

3 months

(0, 11 days, 11 weeks)

7

Pattnaik et al., 2015 [26]

RCT (SM)

29–54

9/11

20 patients

(40 sites)

A. SRP alone (10 sites)

B. SRP plus CHX chip (10 sites)

PERIOCOL-CG™

(2.5 mg CHX from a 20% CHX solution in fish collagen membrane)

PD, CAL, GI, Bacterial Count

3 months

(0, 1, 3)

8

Kumar et al., 2014 [27]

RCT (P)

20–65

15/15

30 patients (30 sites)

A. SRP alone (10 sites)

B. SRP plus CHX chip (10 sites)

C. CHX chip alone (10 sites)

PERIOCOL-CG™

(2.5 mg CHX from a 20% CHX solution in fish collagen membrane)

GI, PPD, CAL, BANA

0, 1, 3 m

9

Medaiah et al. 2014 [28]

RCT (P)

35–55

6/9

15 patients (45 sites)

A. SRP alone (15 sites)

B. SRP plus CHX chip (15 sites)

C. CHX chip alone (15 sites)

Perio Chip®, Perioproducts, Jerusalem, Israel

PI, GI, BOP, PD, CAL

3 months

(0,1,3)

10

Pai et al. 2013 [17]

RCT (P)

35–55

7/8

15 patients (45 sites)

A. SRP alone (15 sites)

B. SRP plus CHX Varnish (15 sites)

C. SRP plus CHX chip (15 sites)

NM

PI, BOP, SBI, PPD, CAL

3 months (0,1,3)

11

Puri et al. 2013 [29]

RCT (SM)

30–50

8/7

15 patients (30 sites)

A. SRP alone (15 sites)

B. SRP plus CHX chip (15 sites)

Perio Chip®, Perioproducts, Jerusalem, Israel

GI, PI, PPD, CAL, TCC

3 months

(0,1,3)

12

Grover et al., 2011 [30]

RCT (P)

30–65

28/12

40 patients (40 sites)

A. SRP alone (20 sites)

B. SRP plus CHX chip (20 sites)

PERIOCOL-CG™

(2.5 mg CHX from a 20% CHX solution in fish collagen membrane)

PPD, CAL, BI and Radiological parameters (bone gain)

3 months (7th day, 1, 2, 3)

13

Sakellari et al., 2010 [31]

RCT (P)

35–75

25/25

50 patients (50 sites)

A. SRP alone (25 sites)

B. SRP plus CHX chip (25 sites)

Perio Chip®, Perioproducts, Jerusalem, Israel

PPD, CAL, BOP, Bacterial Count

6 months (0, 3 weeks, 3,6)

14

Paolantonio et al., 2008

[32]

RCT (SM)

33–65

34/82

116 patients (232 sites)

A. SRP alone (116 sites)

B. SRP plus CHX chip (116 sites)

Perio Chip®, Perioproducts, Jerusalem, Israel

PPD, RAL, BOP, Bacterial Count

6 months (0, 3, 6)

15

Paolantonio et al., 2008

[33]

RCT (SM)

31–63

33/49

82 patients (164 sites)

A. SRP alone (82 sites)

B. SRP plus CHX chip (82 sites)

Perio Chip®, Perioproducts, Jerusalem, Israel

PPD, RAL, BOP, GCF- ALP

6 months (0, 3, 6)